Search for dissertations about: "SNAIL1"

Found 5 swedish dissertations containing the word SNAIL1.

  1. 1. Gene regulation by different proteins of TGFβ superfamily

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Varun Maturi; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EMT; Snail1; ZEB1; TGFβ; BMP; Gene regulation;

    Abstract : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. READ MORE

  2. 2. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    University dissertation from Umeå : Umeå University

    Author : Reshma Sundar; Umeå universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Abstract : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. READ MORE

  3. 3. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    University dissertation from Umeå : Umeå University

    Author : Shyam Kumar Gudey; Umeå universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; patologi; Pathology;

    Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE

  4. 4. The role of transforming growth factor‐β signaling and hypoxia‐inducible factors in renal cell carcinoma

    University dissertation from Umeå : Umeå University

    Author : Pramod Mallikarjuna; Umeå universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; Hypoxia; Renal cell carcinoma; ccRCC; non-ccRCC; transforming growth factor-β; ALK5; pVHL; HIF-α; SNAIL1; molekylärbiologi; Molecular Biology;

    Abstract : Renal cell carcinoma (RCC) is the cancer of the kidneys; about 1100 patients with RCC are diagnosed in Sweden each year. RCC can be classified into several subtypes, clear cell renal cell carcinoma (ccRCC) is most common accounting to about 70% of all RCCs, and also the most lethal; papillary renal cell carcinoma (pRCC) accounts to about 10%‐15%, while chromophobe renal cell carcinoma (chRCC) accounts to about 5% of all RCCs. READ MORE

  5. 5. Not just protein factories : role of ribosome biogenesis as an architect of epithelial-mesenchymal transition and breast cancer progression

    University dissertation from Stockholm : Karolinska Institutet, Dept of Physiology and Pharmacology

    Author : Varsha Prakash; Karolinska Institutet.; Karolinska Institutet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : RNA polymerase I (Pol I)-mediated transcription of ribosomal DNA (rDNA) is considered to be the rate-limiting step in ribosome biogenesis and is a well-known hallmark of cell growth and proliferation. The process of synthesizing new ribosomes is executed by the coordination of multiple complex processes in the nucleolus. READ MORE