Search for dissertations about: "SNP"

Showing result 21 - 25 of 315 swedish dissertations containing the word SNP.

  1. 21. Quality of life and psychological reactions in women on first line chemotherapy for metastatic breast cancer - Correlations to tumour response and predictive factors

    Author : Helene Svensson; Göteborgs universitet.; Gothenburg University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Recurrence; Health-related quality of life; EORTC QLQ-C30; Metastatic breast cancer; Prognostic factors; Chemotherapy; Toxicity; SNP; Psychological reactions;

    Abstract : Background: Health-related quality of life (HRQoL) is an important endpoint in clinical trials and as an aspect that must be considered in the treatment of patients with metastatic breast cancer. Treatment efficacy and toxicity are important factors for HRQoL, so it is imperative to study the effects of oncological treatment in terms of HRQoL. READ MORE

  2. 22. Approaches for analysis of mutations and genetic variations

    University dissertation from Stockholm : KTH

    Author : Afshin Ahmadian; [2001]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; LOH; microsatellite; fragment analysis; DNA sequencing; pyrosequencing; cancer; mutation; variation; SNP; allele-specific extension; apyrase; TECHNOLOGY; TEKNIKVETENSKAP;

    Abstract : Detecting mutations and genomic variations is fundamental indiagnosis, isolating disease genes, association studies,functional genomics and pharmacogenomics. The objective hasbeen to use and further develop a variety of tools andtechnologies to analyze these genetic alterations andvariations. READ MORE

  3. 23. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    University dissertation from Unit of Islet Cell Exocytosis

    Author : Sofia A Andersson; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

    Abstract : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). READ MORE

  4. 24. Gene Mapping in Ficedula Flycatchers

    University dissertation from Uppsala : Universitetsbiblioteket

    Author : Niclas Backström; Hans Ellegren; Juha Merilä; [2009]
    Keywords : collared flycatcher; SNP; linkage disequilibrium; genetic map; pedigree;

    Abstract : In order to get full understanding of how evolution proceeds in natural settings it is necessary to reveal the genetic basis of the phenotypic traits that play a role for individual fitness in different environments. There are a few possible approaches, most of which stem from traditional mapping efforts in domestic animals and other model species. READ MORE

  5. 25. Understanding the Noise Spliceosomal snRNA Profiling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lei Liu Conze; Anders Virtanen; Lars Wieslander; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. READ MORE