Search for dissertations about: "SNPs analysis"

Showing result 1 - 5 of 148 swedish dissertations containing the words SNPs analysis.

2. 1. Novel diagnostic microarray assay formats towards comprehensive on-site analysis

   Author : Jesper Gantelius; Helene Andersson-Svahn; Christer Wingren; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; magnetic microbeads; gold nanobeads; microarrays; lateral flow; on-site diagnosis; SNPs; pestivirus; autoimmunity; contagious bovine pleuropneumonia; comsol multiphysics; finite element method; Microbiology; Mikrobiologi; Biochemistry; Biokemi;

   Abstract : Advances in molecular methods for analyzing DNA, RNA and proteins in humans as well as in other animals, plants, fungi, bacteria or viruses have greatly increased the resolution with which we can study life’s complexity and dynamics on earth. While genomic, transcriptomic and proteomic laboratory tools for molecular diagnosis of disease are rapidly becoming more comprehensive, the access to such advanced yet often expensive and centralized procedures is limited. READ MORE

4. 2. Exploring the Genetics of SLE with Linkage and Association Analysis

   Author : Cecilia Johansson; Marta Alarcón-Riquelme; Peter Gregersen; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic lupus erythematosus; complex disease; linkage analysis; association analysis; Genetik; Genetics; Genetik;

   Abstract : The aim with this thesis has been to identify genes involved in the pathogenesis of Systemic Lupus Erythematosus (SLE). SLE is a systemic autoimmune disorder, most likely caused by both several genetic and environmental factors. READ MORE

5. 3. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

   Author : Igor Bazov; Georgy Bakalkin; Catharina Lavebratt; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; neuropeptides; dynorphin; human brain; alcohol dependence; epigenetics; gene transcription;

   Abstract : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. READ MORE

6. 4. Accessing Genetic Variation by Microarray Technology

   Author : Katarina Lindroos; Edwin Southern; Uppsala universitet; []
   Keywords : Medical sciences; microarrays; SNPs; minisequencing; four-colour detection; allele frequency; population study; evolutionary biology; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Molekylär medicin; Molecular Medicine;

   Abstract : Microarray technology is a promising approach for the simultaneous analysis of multiple single nucleotide polymorphisms (SNPs), which are the most abundant form of genetic variation. In this thesis enzyme-assisted microarray-based methods were developed to improve the accuracy and genotype discrimination power of the current methods for SNP genotyping. READ MORE

7. 5. Predictive Healthcare : Cervical Cancer Screening Risk Stratification and Genetic Disease Markers

   Author : Nicholas Baltzer; Jan Komorowski; Mark Jit; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Cervical Cancer; Screening; Computer Science; Algorithmics; Machine Learning; Genetics; SNPs; Rough Sets; Bioinformatics; Bioinformatik;

   Abstract : The use of Machine Learning is rapidly expanding into previously uncharted waters. In the medicine fields there are vast troves of data available from hospitals, biobanks and registries that now are being explored due to the tremendous advancement in computer science and its related hardware. READ MORE