Search for dissertations about: "SOCS-3"
Found 5 swedish dissertations containing the word SOCS-3.
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1. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes
Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE
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2. Prolactin receptor expression and prolactin-mediated effects in adipose tissue
Abstract : The aim of this study was to investigate the presence of functional prolactin receptors (PRLRs) in white adipose tissue of mice and humans, and the possible functions mediated via PRLRs. In mouse white adipose tissue, three PRLR mRNA isoforms, L-, S2-, and S3-PRLR, and L-PRLR protein expression were detected. READ MORE
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3. The role of miR-203 in keratinocyte biology and psoriasis
Abstract : Psoriasis is one of the most common chronic inflammatory skin diseases. It is a life long suffering disease affecting approximately 2 to 3% of the population in Scandinavia. Significant progress has been made to understand the cellular immunology and biology of psoriasis. READ MORE
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4. Effects of 1,25-dihydroxyvitamin D3 and growth hormone on osteoblast-like cells
Abstract : Bone remodeling, which occurs throughout life in both cancellous and cortical bone, involves mainly the osteoblasts and osteoclasts. The osteoblast is responsible for the production of matrix, which later becomes mineralized. The osteoclast is a large, multinuclear cell, which is responsible for bone resorption. READ MORE
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5. Interleukin-6 as a mediator of insulin resistance
Abstract : A potential role of interleukin (IL)-6 for the metabolic abnormalities seen in obesity and insulinresistance was postulated when it was discovered that circulating IL-6 levels were elevated in obeseand insulin-resistant as well as type 2 diabetic individuals. Later it was shown that the adipose tissuewas a major site of IL-6 production, accounting for 15-35% of the total circulating levels. READ MORE