Search for dissertations about: "SOX10"
Showing result 1 - 5 of 16 swedish dissertations containing the word SOX10.
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1. Alopecia and vitiligo in autoimmune polyendocrine syndrome type I
Abstract : Autoimmune polyendocrine syndrome type I (APS I) is a recessively inherited disease caused by mutations in a recently identified gene, AIRE, on human chromosome 21. APS I patients are affected by autoimmune destruction of multiple endocrine glands and other organs as well as ectodermal structures. READ MORE
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2. The Role of Melanocyte Lineage Genes in Melanoma
Abstract : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. READ MORE
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3. Exploring the Molecular Landscape of Cutaneous Melanoma
Abstract : Cutaneous malignant melanoma (CMM) is one of the most aggressive skin malignancies with poor prognosisfor the patients with metastatic disease. Earlier studies have highlighted the existing molecular diversityamongst CMM tumors. READ MORE
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4. Epidermal Melanocyte Response to Radiotherapy
Abstract : Cutaneous interfollicular melanocytes protect the skin from UV-radiation (UVR), and their response to UVR is well established. To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy (RT) has not been explored. READ MORE
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5. Prognostic Factors in Malignant Melanoma
Abstract : Because of the failure so far to find effective treatment for patients with advanced stages of melanoma, increasing efforts have been made to find prognostic factors identifying patients in the risk zone for development of metastasis.This thesis investigates the prognostic powers of a few selected serological and immunohistochemical biomarkers. READ MORE