Search for dissertations about: "SPHEROIDS"
Showing result 1 - 5 of 55 swedish dissertations containing the word SPHEROIDS.
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1. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE
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2. Utilizing Biopolymers in 3D Tumor Modeling and Tumor Diagnosis
Abstract : Cancer represents a significant global public health challenge and ranks as the second mostcommon cause of death in the United States. The onset of cancer entails an initial phasewhere cells lose their polarity and disconnect from the normal basement membrane, allowingthem to form distinct three-dimensional (3D) configurations that interact with adjacent cellsand the surrounding microenvironment. READ MORE
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3. New preclinical strategies for characterization and development of anticancer drugs
Abstract : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. READ MORE
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4. Cancer Evolution under Chemotherapy Treatment
Abstract : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). READ MORE
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5. Translational genetics identifies a novel target to treat fatty liver disease
Abstract : Fatty liver disease (FLD) is rapidly prevailing as the most common liver disease worldwide, with an estimated of one-quarter of the global population affected. Environmental and genetic determinants contribute to FLD susceptibility. READ MORE