Search for dissertations about: "SPR"

Showing result 21 - 25 of 114 swedish dissertations containing the word SPR.

2. 21. Black Lives, White Quotation Marks : Textual Constructions of Selfhood in South African Multivoiced Life Writing

   Author : Jenny Siméus; Maria Olaussen; Stefan Helgesson; Meg Samuelson; Ashleigh Harris; Linnéuniversitetet; []
   Keywords : HUMANIORA; HUMANITIES; HUMANIORA; HUMANITIES; HUMANIORA; HUMANITIES; Antjie Krog; collaborative autobiography; collaborative life writing; Elsa Joubert; Jonathan Morgan; Kopano Ratele; Margaret McCord; multivoiced life writing; Nosisi Mpolweni; selfhood; South Africa; Zoë Wicomb; English literature; Engelska med litteraturvetenskaplig inriktning;

   Abstract : This thesis focuses on South African multivoiced and collaborative life writing. The analysed primary texts are The Long Journey of Poppie Nongena (1980) by Elsa Joubert, The Calling of Katie Makanya: A Memoir of South Africa (1995) by Margaret McCord, Finding Mr Madini (1999) by Jonathan Morgan and the Great African Spiderwriters, David’s Story (2000) by Zoë Wicomb, and There Was This Goat: Investigating the Truth Commission Testimony of Notrose Nobomvu Konile (2009), co-written by Antjie Krog, Nosisi Mpolweni and Kopano Ratele. READ MORE

4. 22. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors

   Author : Malin Elinder; U. Helena Danielson; Maurizio Botta; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; fragment; screening; reverse transcriptase; microbicides; interaction analysis; NNRTIs; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Abstract : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. READ MORE

5. 23. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

   Author : Helena Nordström; Helena Danielson; Gregg Siegal; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fragment based drug discovery; SPR biosensor; matrix metalloproteinase-12; HIV-1 protease; resistance;

   Abstract : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. READ MORE

6. 24. Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans : Application for Drug Discovery

   Author : Dan Backman; Helena Danielson; Birgitta Tomkinson; Gunnar Henriksson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR Biosensor; Secreted aspartic proteases; Candida albicans; interaction kinetics; drug discovery; protease inhibitor; Biokemi; Biochemistry; Biokemi;

   Abstract : This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. READ MORE

7. 25. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes : Applications for Antiviral Drug Development

   Author : Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; Biochemistry; Biokemi;

   Abstract : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). READ MORE