Search for dissertations about: "SRA - Molekylär biovetenskap"

Showing result 1 - 5 of 20 swedish dissertations containing the words SRA - Molekylär biovetenskap.

  1. 1. Theoretical studies on photophysics and photochemistry of DNA

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Yuejie Ai; Yi Luo; Lluís Blancafort; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry Theoretical chemistry Quantum chemistry; NATURVETENSKAP Kemi Teoretisk kemi Kvantkemi; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : Theoretical studies on biological systems like nucleic acid and protein have been widely developed in the past 50 years and will continue to be a topic of interest in forefronts of natural science. In addition to experimental science, computational modeling can give useful information and help us to understand biochemical issues at molecular, atomic and even electronic levels. READ MORE

  2. 2. Mapping the human proteome using bioinformatic methods

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Linn Fagerberg; Mathias Uhlén; Alvis Brazma; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; proteome; transcriptome; bioinformatics; membrane protein prediction; subcellular localization; protein expression level; cell line; immunohistochemistry; immunofluorescence; NATURAL SCIENCES Biology Other biology Bioinformatics; NATURVETENSKAP Biologi Övrig biologi Bioinformatik; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : The fundamental goal of proteomics is to gain an understanding of the expression and function of the proteome on the level of individual proteins, on the level of defined cell types and on the level of the entire organism. In this thesis, the human proteome is explored using membrane protein topology prediction methods to define the human membrane proteome and by global protein expression profiling, which relies on a complex study of the location and expression levels of proteins in tissues and cells. READ MORE

  3. 3. Ribosome display for selection and evolution of affibody molecules

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Sebastian Grimm; Per-Åke Nygren; Mike Taussig; [2011]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; TECHNOLOGY Bioengineering Genetic engineering including functional genomics; TEKNIKVETENSKAP Bioteknik Genteknik inkl. funktionsgenomik; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. READ MORE

  4. 4. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Camilla Hofström; Torbjörn Gräslund; Serge Muyldermans; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. READ MORE

  5. 5. Structure and spectroscopy of bio- and nano-materials from first-principles simulations

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Weijie Hua; Yi LUO; Mauro Stener; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; soft x-ray spectroscopy; bio- and nano-materials; first-principles simulation; host-guest interaction; generalized energy-based fragmentation; NATURAL SCIENCES Chemistry Theoretical chemistry Quantum chemistry; NATURVETENSKAP Kemi Teoretisk kemi Kvantkemi; NATURAL SCIENCES Chemistry Physical chemistry Spectroscopy; NATURVETENSKAP Kemi Fysikalisk kemi Spektroskopi; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : This thesis is devoted to first-principles simulations of bio- and nano-materials,focusing on various soft x-ray spectra, ground-state energies and structures of isolated largemolecules, bulk materials, and small molecules in ambient solutions.K-edge near-edge x-ray absorption fine structure (NEXAFS) spectra, x-ray emission spectra, andresonant inelastic x-ray scattering spectra of DNA duplexes have been studied by means oftheoretical calculations at the density functional theory level. READ MORE