Search for dissertations about: "SREBP"

Showing result 1 - 5 of 12 swedish dissertations containing the word SREBP.

  2. 1. Growth hormone and PPARalpha in the regulation of genes involved in hepatic lipid metabolism

    Author : Caroline Améen; Göteborgs universitet; []
    Keywords : Growth hormone; insulin; SREBP-1; lipogenic enzymes; microsomal triglyceride transfer protein; PPARalpha; LXRalpha; triglycerides; liver;

    Abstract : Growth hormone (GH) plays a key role in the regulation of lipid and lipoprotein metabolism. Its sexually dimorphic secretory pattern regulates many sex-differentiated functions in the liver, such as triglyceride synthesis and VLDL secretion. READ MORE

  4. 2. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

    Author : Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

    Abstract : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. READ MORE

  5. 3. Studies on the transcriptional regulation of sterol 12alpha-hydroxylase (CYP8B1)

    Author : Yizeng Yang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bile acids; CYP8B1; CYP7A1; transcription; nuclear receptor; PPAR-alpha; HNF4-alpha; FTF; SREBP; thyroid hormones.;

    Abstract : The conversion of cholesterol into bile acids is mainly via two pathways, which are initiated by CYP7A1 and CYP27A1 respectedly. CYP8B1, a microsomal P450 cytochrome, hydroxylates of the steroid nucleus at the C-12alpha position to form 7alpha, 12alpha-dihydroxy-4-cholesten-3-one, a facultative precursor of CA. READ MORE

  6. 4. Studies on the regulatory roles of cholesterol and bile acids

    Author : Charlotte Murphy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cholesterol; cholic acid; bile acids; cholesterol homeostasis; squalene epoxidase; mevalonate kinase; cob I alamin adenotransferase; SREBP; NF-Y;

    Abstract : Cholesterol is essential for normal growth and development in mammals. However, excess cholesterol can be harmful leading to diseases such as atherosclerosis and gallstones. Once formed the ring structure of cholesterol cannot be catabolised by the body and must therefore be converted to other compounds for excretion. READ MORE

  7. 5. Studies on the regulatory role of cholic acid in cholesterol metabolism

    Author : Charlotte Murphy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol is essential for normal growth and development in both man and mouse. However, excess cholesterol can be harmful leading to diseases such as atherosclerosis and gallstones. Once formed cholesterol cannot be catabolised by the body and must therefore be converted to other compounds for excretion. READ MORE