Search for dissertations about: "SSAO"

Showing result 1 - 5 of 6 swedish dissertations containing the word SSAO.

  1. 1. Semicarbazide-sensitive Amine Oxidase (SSAO) – Regulation and Involvement in Blood Vessel Damage with Special Regard to Diabetes : A Study on Mice Overexpressing Human SSAO

    Author : Camilla Göktürk; Lars Oreland; Karin Forsberg-Nilsson; Dan Larhammar; Peter Yu; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; amine oxidases; VAP-1; vascular complications; diabetes; blood pressure; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : Semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6) belongs to a family of copper-containing amine oxidases. READ MORE

  2. 2. Semicarbazide-sensitive amine oxidase and vascular complications in diabetes mellitus : Biochemical and molecular aspects

    Author : Jenny Nordquist; Keith F. Tipton; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; diabetes; SSAO; VAP-1; retinopathy; methylamine; aminoacetone; hydralazine; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Plasma activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO; EC.1.4.3. READ MORE

  3. 3. Regiocontrol in the Heck-reaction and fast fluorous chemistry

    Author : Kristofer Olofsson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; palladium; Heck-koppling; regiokontroll; MAO-hämmare; ssao-hämmare; mikrovågskemi; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : The palladium-catalysed Heck-reaction has been utilised in organic synthesis, where the introduction of aryl groups at the internal, β-carbon of different allylic substrates has been achieved with high regioselectivity.The β-stabilising effect of silicon enhances the regiocontrol in the internal arylation of allyltrimethylsilane, while a coordination between palladium and nitrogen induces very high regioselectivities in the arylation of N,N-dialkylallylamines and the Boc-protected allylamine, producing β-arylated arylethylamines, which are of interest for applications in medicinal chemistry. READ MORE

  4. 4. Early diagnosis of diabetic retinopathy by mass examinations in primary health care

    Author : Lars B. Bäcklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; amaurosis - amine oxidase copper-containing - benzylamine - blindness - diabetes mellitus complications - diabetic retinopathy - Estonia - HbA1c - he services - services research - hemoglobin A; glycosylated - incidence - mass screening - methylamine - photo graphy - physicians; family - prevalence - population - primary health care - prospective studies - registries - rehabilitation centers - semicarbazide-sensitive amine oxidase SSAO -Sweden - vascular adhesion protein- I - vision screening - vision; subnormal - visual acuity;

    Abstract : The general objective of this thesis was to describe a system for fundus photography for early diagnosis of diabetic retinopathy, performed by mobile teams visiting primary health care centres in Stockholm County. Large-scale implementation showed this method to be feasible, acceptable, and popular. READ MORE

  5. 5. Amine oxidases in dental pulp : a study with special regard to a semicarbazide-sensitive amine oxidase with catalytic potency towards serotonin

    Author : Astrid Norqvist-Sjöberg; Lars Oreland; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Abstract : The amine oxidizing capacity of piglet dental pulp tissue has been investigated. At least six separate enzyme activities could be distinguished:- a soluble semicarbazide-sensitive (SSAO) activity towards benzylamine, most likely to be derived from the content of blood plasma within the pulp tissue;- a soluble pulp tissue SSAO activity with most properties in common with the plasma enzyme, however with great efficiency not only regarding benzylamine but also tryptamine;- a tissue bound SSAO activity with activity towards benzylamine, tryptamine, tyramine and ß-phenylethylamine;- a tissue bound semicarbazide-sensitive activity towards serotonin (SSA0-5HT) (a combination of properties never reported before);- a mitochondrially bound and clorgyline-sensitive monoamine oxidase-A (MAO-A) activity with activity towards serotonin;- a mitochondrially bound and deprenyl-sensitive MAO-B activity with activity towards e. READ MORE