Search for dissertations about: "SUGAR CONFORMATION"
Showing result 1 - 5 of 15 swedish dissertations containing the words SUGAR CONFORMATION.
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1. Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics
Abstract : Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on their preferred conformations. READ MORE
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2. A comparative study on sugar beet root (Na⁺+K⁺)MgATPases isolated by different methods
Abstract : Msiribrane bound (Na+ + K+)MgATPases from homogenates of young sugar beet roots were prepared either by differential centrifugations or by an aqueous two-phase system. The properties of the MgATPases were deter- mined in the preparations. Potassium [K (° Rb )] uptake into roots of intact sugar beets was also studied. READ MORE
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3. Stereoelectronic effects in nucleosides and nucleotides
Abstract : This thesis is based on 12 original publications from 1994-98. Intramolecular stereoelectronicforces (anomeric and gauche effects), beside intermolecular forces such as hydrogen bonding,base stacking, electrostatics and hydration, have been found to be responsible for the localstructural changes of DNA and RNA and their components. READ MORE
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4. Studies on the Non-covalent Interactions (Stereoelectronics, Stacking and Hydrogen Bonding) in the Self-assembly of DNA and RNA
Abstract : This thesis is based on ten publications (Papers I-X). The phosphodiester backbone makes DNA or RNA to behave as polyelectrolyte, the pentose sugar gives the flexibility, and the aglycones promote the self-assembly or the ligand-binding process. READ MORE
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5. Physicochemical and Structural Aspects of Nucleic Acids
Abstract : This thesis consists of seven research publications concerning (i) pKa studies of nucleobases in model nucleotides to understand why RNA duplexes are more stable than DNA duplexes (Paper I), (ii) the role of Me(T)-π interactions in the relative stability of DNA-RNA heteroduplexes (Paper II), (iii) pKa measurements in nucleotides with different 2′-substituents (paper III), (iv) a conformation study of constrained sugars and a pKa study of 1-thyminyl to reveal effect of sugar constraints on the pKa of the nucleobase (paper IV), (v) NMR and MD studies of 1′, 2′-oxetane constrained thymidine incorporated Dickerson Drew dodecamer (paper V), (vi) the sequence dependent pKa perturbation of 9-guaninyl moeity in single stranded (ss) DNA and RNA (paper VI), (vii) the non identical chemical nature of internucleotidic phosphates in (ss) RNA using 31P NMR (paper VI), and an alkaline hydrolysis study of phosphodiesters in ssRNAs (paper VII). The architecture of DNA and RNA molecules is determined by (a) hydrogen bonding (b) base stacking (c) a variety of additional non-covalent interactions. READ MORE
