Search for dissertations about: "SWI SNF"

Showing result 11 - 15 of 16 swedish dissertations containing the words SWI SNF.

  2. 11. Chromatin remodelling and gene regulation

    Author : Birgitta Gelius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and some of these are important for gene regulation. READ MORE

  4. 12. Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation

    Author : Dzeneta Vizlin-Hodzic; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Oct4; SAF-A; Brg1; Tpt1; Npm1; transcriptional regulation; cell proliferation; shelterin;

    Abstract : Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene expression, high telomerase activity and specific cell proliferation, characteristics shared with cancer stem cells. READ MORE

  5. 13. Mechanisms of modulation of PDGFRβ signaling

    Author : Niki Sarri; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signalling; phosphatase; MKP2; DUSP4; deubiquitinase; USP4; USP17; E3 ligase; Cbl; TRIM21; endoribonuclease; G3BP1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Platelet-derived growth factors (PDGF) constitute a family of five functional dimers that bind to two structurally related tyrosine kinase receptors i.e. PDGF receptor α and β (PDGFRα and PDGFRβ, respectively), controlling cell growth, proliferation, and migration in cells of mesenchymal origin. READ MORE

  6. 14. Human pluripotent stem cells : effects of handling and microenvironment

    Author : Frida Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pluripotent stem cells hold great promise in regenerative medicine and drug development due to their developmental potential towards multiple lineages. However, there are still hurdles to overcome before these cells are safe enough for clinical use even though attempts have already been initiated. READ MORE

  7. 15. Characterization of candidate disease genes from human chromosomes 11g13 and 22q

    Author : Darek Kedra; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fugu rubripes; 11q13 region; MEN1; menin; GCK; DMPKL; meningioma; clathrin; adaptin; NIPSNAP; synaptogyrin; TOM1; SMARCB1;

    Abstract : Two regions of the human genome, 11q13 and 22q, have been shown to harbor numerous disease-related genes, among them tumor suppressor genes (TSGs). The aim of this project was to construct transcription maps within these chromosomal segments, and thus provide a basis for further analysis of some of the genes for their involvement in disease-related processes. READ MORE