Search for dissertations about: "Sabine Flitsch"

Found 2 swedish dissertations containing the words Sabine Flitsch.

2. 1. Chemo-enzymatic cascades for the synthesis of chiral high-value chemicals

   Author : Lisa Marx; Per Berglund; Sabine Flitsch; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Abstract : Chiral amines are frequent in today´s top selling pharmaceuticals. Classical organic synthesis of pharmaceuticals is often work intensive involving many synthesis steps, the use of protection group chemistry, heavy metal catalysts and chiral crystallization techniques. READ MORE

4. 2. Chemoenzymatic Resolution in Dynamic Systems : Screening, Classification and Asymmetric Synthesis

   Author : Yan Zhang; Olof Ramström; Sabine Flitsch; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; constitutional dynamic chemistry; dynamic systemic resolution; dynamic kinetic resolution; enzyme catalysis; transesterification; enzyme promiscuity; asymmetric synthesis; pattern recognition; self-inhibition.;

   Abstract : This  thesis  is  divided  into  four  parts,  all  centered  around  Constitutional Dynamic  Chemistry  (CDC)  and  Dynamic  Kinetic  Resolution  (DKR)  using biocatalysts for selective transformations, and their applications in screening of bioactive compounds, organic synthesis, and enzyme classification.   In  part  one,  an  introduction  to  CDC  and  DKR  is  presented,  illustrating  the basic  concepts,  practical  considerations  and  potential  applications  of  such dynamic systems, thus providing the background information for the studies in the following chapters. READ MORE