Search for dissertations about: "Saccharin"

Found 5 swedish dissertations containing the word Saccharin.

  2. 1. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    Author : Tina Seifert; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Abstract : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. READ MORE

  4. 2. Engineering of metal microstructures : process-microstructure-property relationships for electrodeposits

    Author : Jens A. D. Jensen; Dieter Landolt; Linköpings universitet; []
    Keywords : ;

    Abstract : The relationships between growth-conditions, topography and microstructure, and physical properties of electrochemically deposited copper, nickel and zinc-iron alloys were studied. Growth was investigated while systematically varying process parameters such as electrolyte chemistry, type and concentration of additives, current density, and mass transport. READ MORE

  5. 3. Appetite regulating neuropeptides in alcohol addiction : focus on melanin concentrating hormone and its mch1-receptor

    Author : Camilla Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Current treatment options for alcohol use disorders are limited in number and have limited efficacy. It is therefore important to find new, more effective medications. READ MORE

  6. 4. Fluorine-Free Phosphorus-Based Ionic Materials and Electrolytes

    Author : Yanqi Xu; Faiz Ullah Shah; Patrik Johansson; Jonas Örtegren; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fluorine-free electrolytes; Physiochemical properties; Nuclear magnetic resonance; Ion interactions; Single crystal structures; Chemistry of Interfaces; Gränsytors kemi;

    Abstract : Due to the successful commercialization of lithium-ion batteries (LIBs), there is a growing interest in developing new battery materials with beneficial electrochemical properties. However, the uneven distribution of lithium resources and the low abundance of lithium in the earth crust are the main obstacles for further development and large-scale production of LIBs. READ MORE

  7. 5. Maternal deprivation and mood stabilizing drugs : effects on rat brain NPY

    Author : Henriette Husum Bak-Jensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Maternal deprivation; stress; mood stabilizing drugs; NPY; mood disorders; depression; anhedonia; Hinders Sensitive Line rats; Amygdala-kindling; microdialysis; RIA; histochemistry.;

    Abstract : Experiences of early adverse life events are more frequent among adult depressed patients than healthy subjects. Studies with non-human primates and rats show that maternal deprivation leads to changes in hypothalamic-pituitary adrenal (HPA)-axis activity/reactivity and increased levels of anxiety and alcohol preference. READ MORE