Search for dissertations about: "Saquinavir"

Found 4 swedish dissertations containing the word Saquinavir.

  2. 1. Antiretroviral treatment of HIV-1 in the central nervous system

    Author : Aylin Yilmaz; Göteborgs universitet; []
    Keywords : HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Abstract : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. READ MORE

  4. 2. Analysis of the interaction between HIV-1 protease and inhibitors : Applications for drug discovery

    Author : Per-Olof Markgren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : The aims of this study were to identify and characterize inhibitors of HIV-l protease aspotential leads in a drug discovery process, and to develop improved methods for suchcharacterization. More than 300 inhibitors, including linear and cyclic peptidomimetictransition state analogs and Cu2+, were analyzed. READ MORE

  5. 3. Studies on the clinical pharmacology of antiretroviral agents

    Author : Filip Josephson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis begins with an account of the development of the antiretroviral treatment paradigm for HIV infection, focusing on the emergence of present day principles of antiretroviral therapy (e.g. READ MORE

  6. 4. In vivo and in vitro models for determination of antiviral activity and resistance

    Author : Ewa Ljungdahl Ståhle; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The AIDS epidemic has been the driving force for the discovery of substances that inhibit the replication of human immunodeficiency virus (HIV). Much interest has earlier focused on a single gene product central to the life cycle of HIV and to all other retroviruses: the reverse transcriptase (RT), the enzyme responsible for synthesis of DNA from viral RNA. READ MORE