Search for dissertations about: "Sarah"

Showing result 1 - 5 of 133 swedish dissertations containing the word Sarah.

  2. 1. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Author : Sarah Piel; Klinisk neurofysiologi; []
    Keywords : mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Abstract : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. READ MORE

  4. 2. Novel Insights into Haematopoietic Stem Cell Regulation and Function

    Author : Sarah Warsi; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematopoiesis; Haematopoietic stem cell; Stem cell regulation; Haematopoietic stem cell transplantation;

    Abstract : The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which is used to treat many haematopoietic disorders. READ MORE

  5. 3. Molecular epidemiology of streptococcus pneumoniae

    Author : Sarah Browall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Streptococcus pneumoniae, also named pneumococci, is often part of the normal flora in the nasopharynx of healthy children. However, pneumococci are also a major cause of morbidity and mortality world-wide, and colonization is required for pneumococci to cause severe invasive diseases such as septicaemia and meningitis. READ MORE

  6. 4. Consequences of multiple sclerosis for patients in Sweden

    Author : Sarah Burkill; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This study aimed to consider consequences of multiple sclerosis for patients in Sweden throughout various stages of the life course. The thesis was separated into four constituent papers, which dealt with different aspects of the disease, its symptoms, and implications at different life stages. READ MORE

  7. 5. Iron isotopes in aquatic systems

    Author : Sarah Conrad; Johan Ingri; Michael Bau; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Applied Geochemistry; Tillämpad geokemi;

    Abstract : The cycling of iron (Fe) is a key component for understanding water quality and biogeochemical processes. It serves as mediator during biotic and abiotic processes, as electron acceptor during the degradation of organic matter, as surface for trace element and organic matter adsorption, and is necessary for primary production processes. READ MORE