Search for dissertations about: "Sec61"
Found 5 swedish dissertations containing the word Sec61.
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1. Integration and topology of membrane proteins
Abstract : Membrane proteins comprise around 20-30% of most proteomes. They play important roles in most biochemical pathways. All receptors and ion channels are membrane proteins, which make them attractive targets for drug design. Membrane proteins insert and fold co-translationally into the endoplasmic reticular membrane of eukaryotic cells. READ MORE
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2. Membrane Protein Biogenesis in Saccharomyces cerevisiae
Abstract : Membranes are hydrophobic barriers that define the outer boundaries and internal compartments of living cells. Membrane proteins are the gates in these barriers, and they perform vital functions in the highly regulated transport of matter and information across membranes. READ MORE
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3. Integration of Transmembrane Helices into the Endoplasmic Reticulum
Abstract : Membrane proteins reside in cell and organelle membranes. They play significant roles in many processes vital to living cells. Receptors and ion channels are examples of membrane proteins that regulate the physiological state of the cell and are attractive targets for drug development. READ MORE
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4. What’s in? What’s out? And how did it get there? : Studies on topologies and insertion of membrane proteins
Abstract : Because of their hydrophobic and hydrophilic nature and the need for a lipid bilayer for retaining the native structure, membrane proteins are hard to study. Nevertheless, they are important, as many of our diseases are related to membrane proteins and around 60% of the different pharmaceutical drugs are directed against a membrane proteins [1]. READ MORE
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5. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum
Abstract : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). READ MORE