Search for dissertations about: "Semliki"

Showing result 1 - 5 of 29 swedish dissertations containing the word Semliki.

  2. 1. Assembly of semliki forest and influenza A viruses

    Author : Hongxing Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki forest virus; influenza virus; virus budding.;

    Abstract : Enveloped viruses contain an external lipid membrane with spikes surrounding their nucleocapsid (NC). The envelope is acquired at a late stage of virus assembly by budding of the NC through a virus-modified host membrane. READ MORE

  4. 2. Assembly and entry mechanisms of Semliki Forest virus

    Author : Bernd Uwe Barth; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest virus; virus assembly; protein oligomerization; virus budding;

    Abstract : The genomes of enveloped viruses are packaged into a core or nucleocapsid (NC) which is surrounded by a lipid membrane with spike proteins. These viruses mature by budding at a membrane of the host cell, usually the plasma membrane (PM), and penetrate into new ones by a virus-host membrane fusion event. READ MORE

  5. 3. Tumor gene therapy using Semliki forest virus replicons

    Author : Paula Colmenero; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest Virus; Alphavirus; Recombinant Vaccine; Tumor Antigen; P815; IL-12;

    Abstract : A major challenge in cancer research is to design effective vaccines that can break immunological tolerance to tumor antigens. Over the past ten years several immunotherapeutic strategies aimed at modulating the patient's immune response to fight cancer have been tested in clinical trials. READ MORE

  6. 4. The role of the capsid protein in Semliki Forest virus assembly

    Author : Kerstin Forsell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest virus; RNA encapsidation; NC assembly; virus budding; RNA uncoating;

    Abstract : Enveloped viruses, like the Alphaviruses, encapsidate their genomes into a nucleocapsid (NC) or core structure which is surrounded by a lipid bilayer (envelope) with spike proteins. The alphavirus Semliki Forest virus (SFV), is an RNA virus with a genomic 42 S RNA of positive polarity. READ MORE

  7. 5. Semliki forest virus-derived packaging system for production of retroviral vectors

    Author : Ke-Jun Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Moloney murine leukemia virus; Semliki Forest virus; gene therapy; retroviral vector; intron; human bone marrow stromal cell;

    Abstract : Gene therapy is a treatment of disease by transfer of genetic material into somatic cells of an individual. Successful gene therapy depends on a delivery system which can efficiently transfer the gene into target cells and lead to high level expression of the gene. READ MORE