Search for dissertations about: "Shotgun proteomics"

Showing result 1 - 5 of 24 swedish dissertations containing the words Shotgun proteomics.

2. 1. Machine Learning methods in shotgun proteomics

   Author : Patrick Truong; Lukas Käll; Peter Nilsson; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry protein summarization Bayesian hierarchical modelling label-free quantification data-independent acquisition mass spectrometry; benchmark mathematical methods; transformers; computational proteomics; proteomics; bioinformatics; bert; ms2 intensity; probabilistic modelling; Biotechnology; Bioteknologi;

   Abstract : As high-throughput biology experiments generate increasing amounts of data, the field is naturally turning to data-driven methods for the analysis and extraction of novel insights. These insights into biological systems are crucial for understanding disease progression, drug targets, treatment development, and diagnostics methods, ultimately leading to improving human health and well-being, as well as, deeper insight into cellular biology. READ MORE

4. 2. Integrative Approaches in Shotgun Proteomics : From sample preparation to multifaceted data analysis

   Author : Mariya Nezhyva; Erik T. Jansson; Per Andrén; Gustaf Christoffersson; Jesper Velgaard Olsen; Uppsala universitet; []
   Keywords : bottom-up proteomics; thermal proteome profiling; mass-spectrometry imaging; data analysis; melanocortin receptor; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Bottom-up proteomics mass-spectrometry gives an opportunity to shed light on var-ious biological aspects/characteristics such as protein composition, its modifications,interactions, and dynamics. Its applications span a wide range of biological sciencesaiming to eventually answer fundamental disease related questions or evaluate drugperformance and predict adverse effects. READ MORE

5. 3. Proteomics in biomarker research : Insights into the effects of aging and environment on biological systems

   Author : Hanna Amelina; Susana Cristobal; Jean-Charles Sanchez; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; proteomics; biomarker; peroxisomes; 2-dimensional gel electrophoresis 2-DE ; mass spectrometry MS ; aging; marine pollution; Biochemistry; Biokemi; Environmental toxicology; Miljötoxikologi; Cell and molecular biology; Cell- och molekylärbiologi; Biochemistry; biokemi;

   Abstract : Proteomics is the global analysis of proteins that covers a broad range of technologies aimed at determining the identity and quantity of proteins expressed in the cell, their three-dimensional structure and interaction partners. In contrast to genome, proteome reflects more accurately on the dynamic state of the cell, tissue, or an organism. READ MORE

6. 4. The accuracy of statistical confidence estimates in shotgun proteomics

   Author : Viktor Granholm; Lukas Käll; Alexey Nesvizhskii; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Proteomics; Peptides; Statistics; Mass spectrometry; Tandem mass spectrometry; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : High-throughput techniques are currently some of the most promising methods to study molecular biology, with the potential to improve medicine and enable new biological applications. In proteomics, the large scale study of proteins, the leading method is mass spectrometry. READ MORE

7. 5. The Heterocysts of Nostoc punctiforme : From Proteomics to Energy Transfer

   Author : Tanai Cardona; Ann Magnuson; Matthias Rögner; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nostoc punctiforme; heterocyst; photosynthesis; thylakoid; isolation; proteomics; photosystem; energy transfer; hydrogen; Biochemistry; Biokemi; biokemi; Biochemistry;

   Abstract : The aim of this thesis is to provide a thorough characterization of the photosynthetic machinery from the heterocysts of Nostoc punctiforme strain ATCC 29133. In this thesis I describe the protocols I have optimized for the isolation of thylakoids from vegetative cells, the purification of heterocysts and the isolation of thylakoids from the purified heterocysts. READ MORE