Search for dissertations about: "Sialic acid"

Showing result 6 - 10 of 53 swedish dissertations containing the words Sialic acid.

  2. 6. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors

    Author : Tiago Bozzola; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sialic Acid; antibacterial agents; Medicinal Chemistry; Synthesis; uptake inhibitors;

    Abstract : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. READ MORE

  4. 7. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

    Author : Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

    Abstract : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. READ MORE

  5. 8. Tailored conjugates of N-acetylneuraminic acid and small molecules that block virus cell attachment and entry

    Author : Emil Johansson; Mikael Elofsson; Niklas Arnberg; Geert-Jan Boons; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; N-acetylneuraminic acid; Neu5Ac; sialic acid; multivalency; Coxsackievirus A24v CVA24v ; Human adenovirus D37; D36; D26; HAdV-D37; HAdV-D26; HAdV-D36 ; 4-O-alkyl Neu5Ac; cryo-EM; branched pleconaril probes; conjunctivitis; organisk kemi; Organic Chemistry;

    Abstract : Viruses are obligate intracellular parasites, unable to replicate without exploiting machinery andmaterials from host cells. Pandemics of viral diseases have had large impacts on human socieities and are continued threats to global health. READ MORE

  6. 9. Sialic acid-dependent binding specificities of Helicobacter pylori and influenza virus. Importance of different parts of the binding sequences

    Author : Petra Johansson; Göteborgs universitet; []
    Keywords : sialic acid; carbohydrates; Helicobacter pylori; influenza virus; binding specificities; glycosphingolipids;

    Abstract : Many viruses and bacteria adhere to host cell glycoconjugates in a specific manner, utilizing selected carbohydrate sequences. The aim of this work was to investigate at a molecular level the interactions of two important human pathogens, influenza virus and Helicobacter pylori, with sialylated carbohydrate structures. READ MORE

  7. 10. Sialic acid : a new potential marker of alcohol abuse

    Author : Maritta Pönniö; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Biological markers have been used for several years to detect heavy alcohol consumption or organ damage induced by alcohol. Early identification of alcohol abuse or alcohol dependence could increase the likelihood of early treatment, thereby reducing health damage and health care costs. READ MORE