Search for dissertations about: "Signal Transducing"
Showing result 1 - 5 of 9 swedish dissertations containing the words Signal Transducing.
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1. Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides
Abstract : The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current study we have investigated the intracellular signalling cascades activated downstream of two separate stimuli: the diabetic milieu and the cardiac glycoside, ouabain. READ MORE
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2. WNT/Frizzled signaling : illuminating the road towards pathway selectivity
Abstract : Cells sense and respond to their environment via receptors embedded in the plasma membrane. Receptors allow flow of information from outside to the inside of the cell and are generally regulated by extracellular molecules and proteins, known as ligands. READ MORE
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3. Transcriptional regulation of development in time and space
Abstract : Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially patterned as the embryo grows. READ MORE
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4. Recognition by and escape from CD8+ T cell immune surveillance in cancer bearing hosts
Abstract : CD8+ T cells ( TCD8+ ) can specifically recognize tumor cells through MHC class I molecules associated with peptides that are 8-l0 amino acid residues long. In recent years, a number of tumor-associated antigens, or their epitopes, have been identified and characterized with the advent of new methods in molecular biology and in peptide isolation. READ MORE
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5. Role of IL-1RAcP and IL-1ra in IL-1 signalling : molecular biological and transgenic studies
Abstract : IL-1 is a proinflammatory cytokine which causes systemic responses such as fever, increased neuroendocrine activity, sympathetic outflow and increased immune responses. Activation of the transcription factor NFkB is one of the molecular mechanisms involved in IL-1 signalling. READ MORE