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Showing result 1 - 5 of 965 swedish dissertations matching the above criteria.
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1. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer
Abstract : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. READ MORE
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2. β-adrenergic stimulation of VEGF gene expression : intracellular signalling pathways
Abstract : In the present study, the intracellular signalling pathway mediating ß-adrenergic stimulation of the expression of the vascular endothelial growth factor (VEGF) gene was investigated.VEGF is an activator of angiogenesis, the formation of new blood vessels, and is considered to be a major regulator of both physiologically and pathologically related angiogenesis, as well as being essential for development of the vascular system. READ MORE
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3. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway
Abstract : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. READ MORE
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4. Injury-Induced Signalling in Arterial Smooth Muscle Cells
Abstract : The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular matrix (ECM) components. It is not a static organ; the components dynamically change and reorganize in response to physiological and pathological stimuli. Vascular injury induces a complex healing process, analogous to generalised wound healing. READ MORE
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5. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes
Abstract : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. READ MORE