Search for dissertations about: "Signature motifs"

Showing result 1 - 5 of 7 swedish dissertations containing the words Signature motifs.

  2. 1. A study of DNA interactive proteins and their origin from thermophilic Siphoviridae phages

    Author : Josefin Ahlqvist; Bioteknik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Thermophilic bacteriophages; Siphoviridae; Genome comparison; Protein production; DNA polymerase I; Holliday junction resolving enzyme; Structure–function relationship; Signature motifs; Bioinformatics;

    Abstract : This thesis covers the results of studies on the amino acid sequence, three-dimensional structure, and activities of two types of DNA-interactive proteins: Holliday Junction resolving enzyme (represented by Hjc_15-6 isolated from phage Tth15-6) and DNA Polymerase I (represented by PolI_G20c, isolated from phage G20c), including studies on their homologous counterparts. As these proteins originate from two different, but related phages that infect Thermus thermophilus, the studies also include the evolutionary relationship between these and other related phages at genomic level. READ MORE

  4. 2. Analyses of genomic and gene expression signatures

    Author : Rickard Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Microarray; comparative genomics; differential gene expression; cell lines; computational biology;

    Abstract : Biology has entered a challenging, information-intense period where computational experiments are complementing traditional experiments. A plethora of new techniques have allowed biological processes to be investigated on a global scale. READ MORE

  5. 3. Global Proteome Survey -Transforming antibody-based affinity proteomics into a global discovery platform

    Author : Niclas Olsson; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity proteomics; recombinant antibodies; Proteomics; mass spectrometry; proteome profiling; breast cancer; antibody specificity;

    Abstract : Proteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurements. READ MORE

  6. 4. Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

    Author : Xiongzhuo Tang; Ylva Engström; Tony Ip; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; POU; Nubbin; Drosophila; intestinal stem cell; epithelium regeneration; midgut; mitosis; Antimicrobial peptides; innate immunity; NF-κB; bacterial infection; transcriptional regulation; homeostasis; Molecular Biology; molekylärbiologi;

    Abstract : Innate immune reactions protect organisms against a variety of infections.  In metazoans, these reactions involve both cellular and humoral responses. The immune responses have to be well-tuned, as excessive immune activation is associated with tissue-specific pathologies. READ MORE

  7. 5. Diverse cyclic dinucleotide signals regulate Escherichia coli lifestyle transition

    Author : Fengyang Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Bacteria have the ability to change their lifestyle to adapt to various environmental conditions. Cyclic dinucleotides (cDNs) are ubiquitous second messengers that can regulate fundamental lifestyle switches, such as motility versus sessility and acute versus chronic virulence, in bacteria. READ MORE