Search for dissertations about: "Simulation of clinical trial"

Showing result 1 - 5 of 15 swedish dissertations containing the words Simulation of clinical trial.

2. 1. Construction, Validation and Application of a Virtual Reality Simulator for the Training of Transurethral Resection of the Prostate

   Author : Reidar Källström; Joar Svanvik; Hans Hjertberg; Peder Funch-Jensen; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgical education; simulation; transurethral resection of prostate; psychometric tests; personality; validation; virtual reality; proficiency based training; objective assessment; MEDICINE; MEDICIN;

   Abstract : The fundamental of surgical training is the traditional apprenticeship method introduced by William Halsted which has been used for the last 100 years. It is based on learning in the operating room (OR) where the resident is guided by an experienced surgeon and gradually and methodically exposed to surgery. READ MORE

4. 2. Studies in health economics : modelling and data analysis of costs and survival

   Author : Mattias Ekman; Handelshögskolan i Stockholm; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : This dissertation consists of six essays in health economics.The first essay, “Economic evaluations in health care: Basic principles and special topics”, serves as an introduction to economic evaluations in health care, including estimations of costs, health effects, and the discount rate. READ MORE

5. 3. Nonparametric tests for comparing two treatments by using ordinal data

   Author : Helen Wahlström; Elisabeth Svensson; Jan Lanke; Sture Holm; Örebro universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Statistik; change; clinical trial; Monte Carlo; ordered categorical data; paired data; permutation test; Pitman efficiency; power; stratification; ties; visual analogue scale; Wilcoxon-Mann-Whitney statistic; statistik; Statistics; Statistik; Statistics; Statistik;

   Abstract : This thesis concerns four nonparametric tests for comparing two treatments in a randomized controlled clinical trial when the main response variable generates discrete or continuous ordinal data and measurements are made at baseline and follow-up. In the Wilcoxon-Mann-Whitney test (WMW) the baseline values are not taken into account at all, but in the other three tests both baseline and follow-up values are used. READ MORE

6. 4. Optimal adaptive designs and adaptive randomization techniques for clinical trials

   Author : Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

   Abstract : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. READ MORE

7. 5. Aspects of analysis of small-sample right censored data using generalized Wilcoxon rank tests

   Author : Marie-Louise Öhman; Hans Nyquist; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Censored generalized Wilcoxon rank test statistics; Variance estimation; Jackknifing; Influence function; Gross error sensitivity; Break-Down point; Sensitivity curve; Location parameter estimation; Product-Limit estimator and Monte-Carlo Simulation; Statistics; computer and systems science; Statistik; data- och systemvetenskap; Statistics; statistik;

   Abstract : The estimated bias and variance of commonly applied and jackknife variance estimators and observed significance level and power of standardised generalized Wilcoxon linear rank sum test statistics and tests, respectively, of Gehan and Prentice are compared in a Monte Carlo simulation study. The variance estimators are the permutational-, the conditional permutational- and the jackknife variance estimators of the test statistic of Gehan, and the asymptotic- and the jackknife variance estimators of the test statistic of Prentice. READ MORE