Search for dissertations about: "Single cell proteomics"

Showing result 1 - 5 of 33 swedish dissertations containing the words Single cell proteomics.

  2. 1. Spatiotemporal characterization of the human proteome

    Author : Diana Mahdessian; Emma Lundberg; Arne Lindqvist; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Spatial proteomics; Spatiotemporal proteomics; Immunofluorescence; Human Protein Atlas; Cell compartments; Single cell proteomics; Cell cycle; Cancer;

    Abstract : Characterizing the molecular components of the basic unit of life; the cell, is crucial for a complete understanding of human biology. The cell is divided into compartments to create a suitable environment for the resident proteins to fulfill their functions. READ MORE

  4. 2. Exploring human variations by droplet barcoding

    Author : Pontus Höjer; Afshin Ahmadian; Pelin Sahlén; Lars Feuk; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; droplets; linked-read sequencing; DNA barcoding; proteomics; genomics; single cell; single extracellular vesicle; single exosome; pipelines; Biotechnology; Bioteknologi;

    Abstract : Biological variations are being explored at ever-increasing rates through the rapid advancement of analytical techniques. Techniques like massively parallel sequencing empower scientists to accurately differentiate individuals’ genetic compositions, cellular functionalities, and healthy tissue from diseased. READ MORE

  5. 3. The release of histone proteins from cells via extracellular vesicles

    Author : Uma Muthukrishnan; Jonathan Gilthorpe; Miles Trupp; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone; extracellular vesicles; exosomes; extracellular histones extracellular DNA; cellular stress; proteomics; ESCRT complex; Lrrn1; mid-hindbrain organizer; ovarian cancer; ascites;

    Abstract : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. READ MORE

  6. 4. Finding order in chaos : Dissecting single-cell heterogeneity in space and time

    Author : Christian Gnann; Emma Lundberg; Manuel D Leonetti; Lucas Pelkmans; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-genetic single-cell heterogeneity; cell cycle; metabolism; imaging-based subcellular proteomics; phosphoproteomics; icke-genetisk single-cell heterogenitet; cellcykel; metabolism; bildbaserad subcellulär proteomik; fosfoproteomik; Biotechnology; Bioteknologi;

    Abstract : The cell is the smallest unit of life and contains DNA, RNA, proteins and a variety of other macromolecules. In recent years, technological advances in the field of single cell biology have revealed a staggering amount of phenotypic heterogeneity between cells in a population, which were previously considered homogenous. READ MORE

  7. 5. Spatiotemporal Profiling of Human Development Using Multiplexed Imaging

    Author : Sanem Sariyar; Emma Käller Lundberg; Burcu Ayoglu; Gunilla Westergren-Thorsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; human development; organ development; spatial proteomics; single-cell proteomics; proliferation; immune system; mänsklig utveckling; organutveckling; spatial proteomik; single-cell proteomik; proliferation; immunsystem; Biotechnology; Bioteknologi;

    Abstract : Human development is complex and intricate, where the positions of cells, expression of key markers, and cell-cell interactions contribute to the development of various organs from different germ layers and the establishment of the body axis. Therefore, understanding human development within spatial and temporal aspects is crucial. READ MORE