Search for dissertations about: "Site-specific modification"

Showing result 11 - 15 of 18 swedish dissertations containing the words Site-specific modification.

  2. 11. Chemical Synthesis of Affibody Molecules for Protein Detection and Molecular Imaging

    Author : Torun Ekblad; Amelie Eriksson Karlström; Per-Åke Nygren; Harald Kolmar; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; peptide synthesis; protein detection; molecular imaging; Bioengineering; Bioteknik;

    Abstract : Proteins are essential components in most processes in living organisms. The detection and quantification of specific proteins can be used e.g. as measures of certain physiological conditions, and are therefore of great importance. READ MORE

  4. 12. RNA modifications and post-transcriptional control in cancer and stem cells

    Author : Giulia Beneventi; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; Pseudouridine; 2’-O-methylation; Splicing; Translation; non-coding RNAs; Cancer; Stem cells; Differentiation; Stress response;

    Abstract : Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. READ MORE

  5. 13. Cellobiohydrolase I as a chiral sector

    Author : Mikael Hedeland; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : The protein cellobiohydrolase I (CBH I) immobilized on silica particles has been used as a chiral selector in liquid chromatography (LC) and the free enzyme has served as a chiral complexing agent in the background electrolyte in capillary electrophoresis (CE) using the partial tilling technique.The CE systems were much more efficient and more solutes could be enantioseparated than in the LC systems. READ MORE

  6. 14. Using peptide-phage display to capture conditional motif-based interactions

    Author : Gustav Sundell; Ylva Ivarsson; Per Jemth; Attila Reményi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interaction; PDZ domain; phosphorylation; peptide-phage display; ProP-PD; phospho-peptide; phosphomimetic substitution; Scribble; NMR; DLG1; PTM; affiinity; Biokemi; Biochemistry;

    Abstract : This thesis explores the world of conditional protein-protein interactions using combinatorial peptide-phage display and proteomic peptide-phage display (ProP-PD). Large parts of proteins in the human proteome do not fold in to well-defined structures instead they are intrinsically disordered. READ MORE

  7. 15. Overcoming delivery challenges in stem cell biology with nanotechnology

    Author : Ludwig Schmiderer; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The discovery of the CRISPR-Cas9 system has revolutionized several areas of biological research by making genome engineering easy, affordable, fast, accessible and scalable. One field that has not yet benefited from this technological advance is that of mitochondrial DNA research. READ MORE