Search for dissertations about: "Skeletal: innervation"

Found 5 swedish dissertations containing the words Skeletal: innervation.

  2. 1. Peptidergic innervation of periarticular tissue : a study in the rat

    Author : Paul Ackermann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Immunohistochemistry; radioimmunoassay; pain measurement; Achilles tendon; collateral ligaments; joint capsules; tendon rupture; regeneration; peripheral nervous system; neuropeptides; delta opioid receptor;

    Abstract : Painful musculo-skeletal disorders pose a tremendous burden on the healthcare system, the main reason being the limited knowledge of the underlying pathomechanisms and lack of specific treatment. Hypothetically, the peripheral nervous system in the musculo-skeletal tissues plays an important role in the regulation of pain, inflammation, vasoactivity and also tissue repair. READ MORE

  4. 2. Sarcopenia

    Author : Erik Edström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aging; sarcopenia; atrophy; regeneration; innervation; dietary restriction;

    Abstract : Sarcopenia (Greek; sarcos: flesh, and penia: poverty) is the pronounced muscle loss that affects the aging population. Sareopenia of the leg muscles results in loss of independence and increased morbidity in the elderly. Emphasizing hind limb motor function, this thesis investigates different aspects of aging and sarcopenia in a rodent model. READ MORE

  5. 3. Bone Development and the Nervous System

    Author : Gregor Sisask; Olof Nilsson; Anders Bjurholm; Kenneth B Jonsson; André Stark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi;

    Abstract : Innervation of bone influence bone modeling, growth and remodeling. Pro-inflammatory cytokines released after tissue trauma are recognized as neurotrophic factors as well as factors influencing bone formation. The Wnt signaling pathway, essential for cell migration during embryogenesis is found to influence bone formation during fracture healing. READ MORE

  6. 4. Human muscle spindles : complex morphology and structural organisation

    Author : Jing-Xia Liu; William K. Ovalle; Umeå universitet; []
    Keywords : human; muscle spindle; intrafusal fiber; aging; biceps brachii; deep muscles of the neck; MyHC; mATPase; SERCA; anatomi; Human Anatomy;

    Abstract : Muscle spindles are skeletal muscle mechanoreceptors that mediate the stretch reflex and provide axial and limb position information to the central nervous system. They have been proposed to play a major role in the pathophysiology of muscle pain. READ MORE

  7. 5. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

    Author : Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

    Abstract : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. READ MORE