Search for dissertations about: "Skeletal metastases"

Showing result 1 - 5 of 12 swedish dissertations containing the words Skeletal metastases.

2. 1. Artificial Intelligence-based Assessment of Prostate Cancer Metastases in PET/CT

   Author : Sarah Lindgren Belal; Malmö Nuklearmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Artificial intelligence AI ; Convolutional neural networks CNN ; PET CT; Prostate cancer; Automated; Tumor burden; Bone metastases; Lymph node metastases;

   Abstract : Background: Quantification of tumor burden from bone scan in the form of automated Bone Scan Index (aBSI) has been validated as an imaging biomarker for patients with prostate cancer. Positron emission tomography combined with computed tomography (PET/CT) is more sensitive and accurate compared to conventional imaging such as bone scan. READ MORE

4. 2. On the Role of Osteoprotegerin/RANK/RANKL System in the Interaction between Prostate Cancer and Bone

   Author : Hendrik Penno; Östen Ljunggren; Olof Nilsson; Andreas Kindmark; Pernilla Lundberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metastases; bone; prostate cancer; osteoprotegerin; RANKL; osteoporosis; genetics; polymorphisms; Orthopaedics; Ortopedi;

   Abstract : Metastases to bone are observed in around 80% of prostate cancer patients and represent the most critical complication of advanced prostate cancer. Unlike other solid tumors that are associated with osteolytic bone metastases, prostate cancer bone metastases stimulate osteoblastic activity with sclerosis in the bone lesions as a consequence. READ MORE

5. 3. Resection of colorectal liver metastases - Impact of preoperative chemotherapy

   Author : Sam Eriksson; Lund Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal liver metastases; Preoperative chemotherapy; Liver resection; Hepatic microcirculation; Sarcopenia;

   Abstract : Background Colorectal cancer is a leading cause of cancer related death worldwide. 20-30 % of patients will develop colorectal liver metastases (CRLMs). Surgical resection is the mainstay of treatment for CRLMs, and is often combined with perioperative chemotherapy, which can prolong progression-free survival after resection. READ MORE

6. 4. Metastatic bone disease

   Author : Rikard Wedin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : cytology; epidemiology; metastatic bone disease; pathologic fracture; prognosis; radiotherapy; skeletal metastasis; surgical therapy; survival; MIB; p53; ER; PgR;

   Abstract : Aim: To evaluate epidemiology, prognosis and diagnostics in metastatic bone disease and identify risk factors for failure after operation for pathologic fracture. Patients: The study was based on patients treated for skeletal metastases, myeloma or lymphoma between 1986 and 1998 at the Oncology Service, Department of Orthopedics, Karolinska Hospital and on patients diagnosed with symptomatic skeletal metastases 1989-1994 in the Stockholm Region. READ MORE

7. 5. Turning data into decisions : clinical decision support in orthopaedic oncology

   Author : Jonathan A Forsberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: The treatment of patients with skeletal metastases is predicated on each patient’s estimated survival. In order to maximize function and quality of life, orthopaedic surgeons must carefully avoid over- or undertreatment of the disease. READ MORE