Search for dissertations about: "Skin immunology"
Showing result 1 - 5 of 41 swedish dissertations containing the words Skin immunology.
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1. The Impact of Tryptase and Epigenetic Mechanisms on Mast Cells
Abstract : Mast cells have a large influence on multiple immune-mediated responses, including allergic conditions, and they have been implicated in various diseases such as arthritis and cancer. Mastocytosis is characterized by abnormal mast cell proliferation induced by mutations in KIT, the stem cell factor (SCF) receptor. READ MORE
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2. Early life cytokines, viral infections and IgE-mediated allergic disease
Abstract : Background: The reasons why some individuals become IgE-sensitised and allergic are largely unknown, though genetic- and early life environmental factors seem to be of importance.Objective: The overall aim of this thesis was to investigate the relationship between IgE-sensitisation and allergic disease, viral infections, genetic markers and early life cytokines. READ MORE
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3. Immunologic aspects of the pathogenesis of human onchocerciasis
Abstract : Onchocerciasis, or river blindness, is a parasitic disease that affects more than 20 million people globally. The induction of pathology is directly related to the presence and destruction of the microfilarial stages (mf) of this filarial nematode. READ MORE
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4. Harnessing the immunoregulatory capacity of single-stranded oligonucleotides to modulate innate immunity
Abstract : As the first line of defense, the innate immune system is exceptionally efficacious against invading pathogens but must be tightly regulated to avoid immune-related pathogenesis. Accordingly, the innate immune system recognizes highly conserved components associated with infections and damaged cells using a limited number of pattern-recognition receptors (PRRs), which are differentially expressed across cell types. READ MORE
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5. Studies of cell-on-chip technology and basophil regulation for improved allergy diagnostics
Abstract : Allergic diseases affect approximately 30% of adults and has an impact on both the individual’s quality of life as well as an economic impact on society. Two effector cells involved in allergic disease are mast cells and basophils, where basophils are more readily available in blood and therefore of great interest when studying allergy. READ MORE