Search for dissertations about: "Smac"

Showing result 1 - 5 of 9 swedish dissertations containing the word Smac.

  2. 1. Smac and Smac mimetics in breast cancer cell death

    Author : Christian Holmgren; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell death; breast cancer; apoptosis; Smac mimetics; Smac; protein kinase C; TRAIL; IAP; TNFα;

    Abstract : .... READ MORE

  4. 2. Roles of protein kinase C in cell death and breast cancer

    Author : Louise Cornmark; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; protein kinase C; apoptosis; cell death; Smac; Smac mimetics; IAP; stanniocalcin-1;

    Abstract : Aberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. READ MORE

  5. 3. Mechanisms of TRAIL- and Smac mimetic-induced cell death and phenotypical changes in breast cancer

    Author : Victoria Granqvist; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; TRAIL; Smac mimetics; Cell death; interferon beta; NF-kappa B;

    Abstract : .... READ MORE

  6. 4. Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer

    Author : Gry Kalstad Lönne; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Several protein kinase C (PKC) isoforms have been suggested as potential targets for breast cancer therapy. To explore the role for PKC isoforms in processes that facilitates malignant progression and the utility of PKC isoforms as biomarkers in breast cancer, we designed a study where we evaluated the expression of PKCα, δ, and ε in primary breast cancers as well as in breast cancer cell lines. READ MORE

  7. 5. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance

    Author : Andreas Tyler; Kjell Grankvist; Simon Ekman; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin resistance; exosomes; gb3; HSP70; the Bcl-2 family; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi; onkologi; Oncology;

    Abstract : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. READ MORE