Search for dissertations about: "Smad7"

Showing result 1 - 5 of 19 swedish dissertations containing the word Smad7.

  1. 1. Smad7 in TGF-β Signalling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Greger Brodin; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; TGF-β; Smad7; Prostate; Transcription; Gene targeting; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Members of the transforming growth factor-β (TGF-β) superfamily of growth and differentiation factors regulate a vast array of biological functions in the adult, and are of great importance in governing cell fate determination and patterning in the developing embryo. The TGF-β signal is propagated intracellularly by Smad proteins resulting in transcriptional responses. READ MORE

  2. 2. The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Ekman; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta; cell migration; invasion; apoptosis; Smad7; APC; ATM; TRAF6; p53; PC3U; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. READ MORE

  3. 3. Smad signaling in hematopoietic stem cell biology

    University dissertation from Molecular Medicine and Gene Therapy, Lund University

    Author : Göran Karlsson; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smad7; Smad4; microarray; retroviral-mediated gene expression; conditional knockout; transforming growth factor beta; smad signaling; hematopoiesis; hematopoietic stem cells; Alk5; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Hematopoietic stem cells (HSCs) are primitive tissue-specific somatic stem cells, responsible for the maintenance and replenishment of the bone marrow (BM) and subsequently the entire blood system. The never-ending ability to differentiate into all the mature hematopoietic lineages makes these HSCs attractive candidates for use in future regenerative medicine. READ MORE

  4. 4. 2-ME-Induced Apoptotic Signalling in Prostate Cancer PC3 Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Padideh Davoodpour; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Prostate cancer; 2-methoxyestradiol; apoptosis; shb; Smad7; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi;

    Abstract : Prostate cancer is common in the Western society and current treatments are often associated with side effects, therefore improved therapeutic strategies are desired. 2-methoxyestradiol (2-ME), an endogenous metabolite of estradiol-17β inhibits tumor growth in vivo as it prevents angiogenesis. 2-ME has also direct cytotoxic effects on tumor cells. READ MORE

  5. 5. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Edlund; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-beta; cytoskeleton; GTPases; mitogen-activated protein kinase kinase 3; TGF-beta-activated kinase 1; Apoptosis; Smad7; beta-catenin; p38 MAPK; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. READ MORE