Search for dissertations about: "Sofia Gustafsson"

Found 3 swedish dissertations containing the words Sofia Gustafsson.

  1. 1. Cannabinoids as modulators of cancer cell viability, neuronal differentiation, and embryonal development

    University dissertation from Umeå : Umeå universitet

    Author : Sofia Gustafsson; Umeå universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; cell viability; neuronal differentiation; colorectal cancer; chick embryo; biokemisk farmakologi; biokemisk farmakologi; Toxicology; toxikologi;

    Abstract : Cannabinoids (CBs) are compounds that activate the CB1 and CB2 receptors. CB receptors mediate many different physiological functions, and cannabinoids have been reported to decrease tumor cell viability, proliferation, migration, as well as to modulate metastasis. READ MORE

  2. 2. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Gustafsson; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. READ MORE

  3. 3. Characterization of HCV Protease Inhibitors Inhibition and Interaction Studies with Applications for Drug Discovery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Svahn Gustafsson; Uppsala universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

    Abstract : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. READ MORE