Search for dissertations about: "Solid tumors"

Showing result 1 - 5 of 144 swedish dissertations containing the words Solid tumors.

  2. 1. Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies

    Author : Linda Sandin; Thomas Tötterman; Mangsbo Sara; Fredrik Eriksson; Loskog Angelica; Ola Winqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ checkpoint blockade; antibody-mediated tumor immunotherapy; CTLA-4; CD40; monoclonal antibodies; experimental animal model; Fc gamma receptor; Medical Science; Medicinsk vetenskap;

    Abstract : Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. READ MORE

  4. 2. CD40L Gene Therapy for Solid Tumors

    Author : Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

    Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE

  5. 3. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

    Author : Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
    Keywords : Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

    Abstract : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. READ MORE

  6. 4. Computed tomography based assessment of treatment response in solid tumors

    Author : Chikako Suzuki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A “substantial evidence” of effectiveness is required for new cancer treatment regimens to be approved. Objective tumor shrinkage/enlargement has been adopted as an indicator of drugs efficacy. The change of tumor size is assessed and quantified by various radiological techniques; most commonly computed tomography (CT). READ MORE

  7. 5. Mapping the immune landscape in solid tumors : implications for immunotherapy

    Author : Emelie Foord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our cells are programmed with various safety mechanisms to avoid transformation into tumor cells. In case these fail, we have a guarding immune system ready to recognize and eliminate these cells. Despite these safety measurements, cancer is one of the leading causes of death worldwide. The tumor cells find ways to escape the immune system. READ MORE