Search for dissertations about: "Solute carrier"

Showing result 1 - 5 of 11 swedish dissertations containing the words Solute carrier.

  1. 1. Atypical Solute Carriers Identification, evolutionary conservation, structure and histology of novel membrane-bound transporters

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emelie Perland; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Major facilitator superfamily; solute carrier; transporter; protein expression; mRNA expression; phylogenetic clustering; orthologues; co-expression; subcellular location; nutrition.; Neuroscience; Neurovetenskap;

    Abstract : Solute carriers (SLCs) constitute the largest family of membrane-bound transporter proteins in humans, and they convey transport of nutrients, ions, drugs and waste over cellular membranes via facilitative diffusion, co-transport or exchange. Several SLCs are associated with diseases and their location in membranes and specific substrate transport makes them excellent as drug targets. READ MORE

  2. 2. Characterization of Amino Acid Transporters in the Brain Molecular and Functional Studies of Members within the Solute Carrier Families SLC38 and SLC6

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Hägglund; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid transporter; Solute Carrier; Glutamine; Leucine; SNAT; B0AT; Neuroscience; Neurovetenskap;

    Abstract : Solute carriers (SLCs) comprise the largest group of transporters in humans and there are currently 52 SLC families. They are embedded in cellular membranes and transport numerous molecules; defects in many of the genes encoding SLCs have been connected to pathological conditions, and several SLCs are potential drug targets. READ MORE

  3. 3. Characterization of Centrally Expressed Solute Carriers Histological and Functional Studies with Transgenic Mice

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sahar Roshanbin; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLC; Solute carriers; Amino acid transporter; PAT; B0AT2; mTORC1; Medical Science; Medicinsk vetenskap;

    Abstract : The Solute Carrier (SLC) superfamily is the largest group of membrane-bound transporters, currently with 456 transporters in 52 families. Much remains unknown about the tissue distribution and function of many of these transporters. READ MORE

  4. 4. Characterization of Amino Acid Transporters Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofie Victoria Hellsten; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carriers; amino acid transporter; SLC38 family; SLC38A8; SNAT8; SLC38A10; SNAT10; SLC38A9; SNAT9; amino acid starvation; AAR; mTORC1; Neuroscience; Neurovetenskap;

    Abstract : In cells and organelles transporters are responsible for translocation of amino acids, sugars and nucleotides among others. In the central nervous system (CNS), amino acid transporters can function as neurotransmitter transporters and nutrient sensors. READ MORE

  5. 5. Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonathan Cedernaes; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adhesion GPCR; delta-5 desaturase; delta-6 desaturase; desaturase index; Diet-induced obesity; estimated desaturase activity; fatty acid composition; gas chromatography; gastrointestinal tract; G-protein coupled receptor; high-fat diet; intestine; linoleic acid; liver; mRNA expression; palmitoleic acid; plasma; phospholipids; proximodistal; RT-qPCR; solute carrier; SCD-1; SCD-16; SCD-18; stearoyl-CoA desaturase; subcutaneous adipose tissue; subsection; triacylglycerols.; Medical Genetics; Medicinsk genetik; Nutrition; Nutrition; Näringslära; Nutrition;

    Abstract : The gastrointestinal tract (GIT) regulates nutrient uptake, secretes hormones and has a crucial gut flora and enteric nervous system. Of relevance for these functions are the G protein-coupled receptors (GPCRs) and the solute carriers (SLCs). READ MORE