Search for dissertations about: "Solute carrier"
Showing result 6 - 10 of 18 swedish dissertations containing the words Solute carrier.
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6. Characterization of Amino Acid Transporters : Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38
Abstract : In cells and organelles transporters are responsible for translocation of amino acids, sugars and nucleotides among others. In the central nervous system (CNS), amino acid transporters can function as neurotransmitter transporters and nutrient sensors. READ MORE
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7. Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet
Abstract : The gastrointestinal tract (GIT) regulates nutrient uptake, secretes hormones and has a crucial gut flora and enteric nervous system. Of relevance for these functions are the G protein-coupled receptors (GPCRs) and the solute carriers (SLCs). READ MORE
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8. The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse
Abstract : The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. READ MORE
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9. In vitro and in silico prediction of drug-drug interactions with transport proteins
Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE
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10. Determining Ligand- and Lipid- Interactions of SLC Transporters
Abstract : Solute carrier transporters (SLCs) mediate the inter- and intra- cellular trafficking of a plethora of substrates and are essential to cell homeostasis. Despite their importance to human physiology and their potential as therapeutic targets, many SLCs are considered orphans as the physiological substrate has not been experimentally determined. READ MORE