Search for dissertations about: "Sonic hedgehog"

Showing result 1 - 5 of 16 swedish dissertations containing the words Sonic hedgehog.

  2. 1. Mechanisms controlling striatal projection neurone generation, from patterning to early differentiation

    Author : Håkan Toresson; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pbx; meis; sonic hedgehog; small eye; pax6; gsh2; gsh1; cerebral cortex; striatum; telencephalon; mutant; development; mouse; embryo; retinoic acid; Clinical biology; Klinisk biologi;

    Abstract : The striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. READ MORE

  4. 2. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects

    Author : André Vicente; Fatima Pedrosa Domellöf; Berit Byström; Luis Abegão Pinto; Jing-Xia Liu; Anders Ivarsen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aniridia; aniridia-related keratopathy; PAX6; keratoplasty; fetal cornea; Notch1; Wnt; sonic hedgehog; mTOR; keratocyte; oftalmiatrik; ophthalmology;

    Abstract : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. READ MORE

  5. 3. Molecular and Cellular Control of Palate Development in the Mouse

    Author : Forugh Vazirisani; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cleft palate; fate mapping; Sonic hedgehog; apoptosis; extracellular matrix; mouse;

    Abstract : The formation of a definitive secondary palate in mammals is a multistep process that comprises growth, elevation, contact and fusion of the two palatal shelves. Disruption at any step generates cleft palate, a major congenital birth defect. Therefore, it is important to understand the mechanisms governing normal palate development. READ MORE

  6. 4. Molecular complexities of patched signaling in cancer development

    Author : Fahimeh Rahnama; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Basal Cell Carcinoma; Patched; Sonic Hedgehog; Desert Hedgehog; Splice variants; Skin;

    Abstract : Basal Cell Cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. BCCs mainly occur as sporadic tumors but can also be found in a hereditary form in the Nevoid Basal Cell Carcinoma Syndrome (NBCCS). READ MORE

  7. 5. Genetic studies of congenital upper limb anomalies

    Author : Tobias Laurell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The overall aim of the work reported in this thesis is to improve epidemiological and genetic knowledge of congenital upper limb anomalies (CULA). To accomplish the specific aims of each paper several different methods and approaches have been used such as register studies, array comparative genome hybridization, Sanger sequencing, exome sequencing and functional studies using Lacz enhancer assay, Zebrafish morpholinos and computational transcription factor binding site prediction. READ MORE