Search for dissertations about: "Staffan Bohm"

Found 4 swedish dissertations containing the words Staffan Bohm.

  1. 1. Zonal organization of the mouse olfactory systems

    Author : Fredrik Gussing; Staffan Bohm; Anna Berghard; Diego Restrepo; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; olfactory; vomeronasal; gene expression; zone; organization; behavior; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Animals survey their environment for relevant odorous chemical compounds by means of the olfactory system. This system is in most vertebrates divided into a main and accessory olfactory system with two specialized neuroepithelia, the olfactory and the vomeronasal epithelium, respectively. READ MORE

  2. 2. Vitamin A regulated neuronal regeneration and homeostasis

    Author : Sofia Håglin; Anna Berghard; Staffan Bohm; Leif Carlsson; Ola Hermanson; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Activity dependent; Adult stem cells; Ageing; CYP26B1; Homeostasis; Metaplasia; Neurogenesis; Olfactory epithelium; Regeneration; Respiratory epithelium; Retinoic acid; Sensory map; Vitamin A;

    Abstract : The olfactory epithelium is a dynamic tissue maintained by continuous neurogenesis throughout life. Upon injury, neurons and other olfactory cell types are regenerated through proliferation of horizontal stem cells. Some genes that regulate vitamin A metabolism are spatially expressed in the olfactory epithelium. READ MORE

  3. 3. Effects of retinoic acid in the mouse olfactory sensory systems

    Author : Maria Hörnberg; Staffan Bohm; Finn Hallböök; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; olfactory; retinoic acid; neuron survival; Molecular biology; Molekylärbiologi;

    Abstract : A common characteristic in neurodegenerative diseases of the brain is death of specific neuronal populations. The lack of neuron proliferation and axon extension in most parts of the central nervous system leads to chronic loss of neurons in the case of injury or disease. READ MORE

  4. 4. Activity-regulated retinoic acid signaling in olfactory sensory neurons

    Author : Hande Login; Staffan Bohm; Mattias Alenius; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse olfactory system; RA; neuronal activity; CNG; Cyp26B1; BACE1; Kirrel-2; molekylärbiologi; Molecular Biology;

    Abstract : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. READ MORE