Search for dissertations about: "Stat1"

Showing result 16 - 20 of 27 swedish dissertations containing the word Stat1.

  2. 16. Prostaglandins and angiogenesis in experimental cancer

    Author : Hans Axelsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; dorsal skin fold chamber; prostanoids; PGE2; indomethacin;

    Abstract : Background and aim. Genes, proteins and pathways have been identified and suggested as potential targets in tumor angiogenesis, but current anti-angiogenic therapies have provided only modest benefits in survival of cancer patients. READ MORE

  4. 17. Etiologic, diagnostic and prognostic factors in vulvar cancer

    Author : Gunnel Lindell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : sentinel node biopsy;

    Abstract : Vulvar Squamous Cell Carcinoma (VSCC) can be divided into two subgroups basaloid and/or warty (HPV-associated) and keratinizing/non-keratinizing carcinomas (not HPV-associated). The inguinal lymph node status represents the most powerful prognostic factor. READ MORE

  5. 18. Platelet-derived growth factor-induced signal transduction

    Author : Sigrídur Valgeirsdóttir; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. READ MORE

  6. 19. Leukocyte activation in newborns in relation to prenatal stress

    Author : Elham Yektaei-Karin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide LL-37 associated to different degrees of fetal stress and delivery modes. We know that delivery is associated to fetal stress including release of cortisol and cathecolamines. READ MORE

  7. 20. Shedding light on the STAT3 small molecule inhibitor field

    Author : Sander Busker; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. READ MORE