Search for dissertations about: "Stat1"

Showing result 6 - 10 of 27 swedish dissertations containing the word Stat1.

  2. 6. Therapeutic response in human cancers : the dual role of STAT signalling

    Author : Iryna Kolosenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects by regulating gene transcription. READ MORE

  4. 7. Innate immunity to intracellular bacterial infections

    Author : Christian Trumstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Intracellular bacterial pathogens have developed mechanisms to enter and invade cells, to survive the immune response and to replicate inside the host. We studied the innate mechanisms that have evolved in the host to battle intracellular bacterial pathogens, such as the obligate intracellular Chlamydia pneumoniae and the facultative intracellular Listeria monocytogenes, which invade the respiratory and the gastrointestinal tracts in humans. READ MORE

  5. 8. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Author : Yinghua Zhou; Uppsala universitet; []
    Keywords : Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. READ MORE

  6. 9. Molecular Screening for Target Discovery in Cancer

    Author : Mårten Fryknäs; Anders Isaksson; Ulf Pettersson; Hugh Salter; Uppsala universitet; []
    Keywords : Genetics; Cancer; Drug resistance; Microarray; High-throughput screening; Genetik;

    Abstract : Cancer is one of the major causes of death in the western world. Resistance to anti-cancer drugs and diagnostic difficulties are major obstacles to successful treatment. READ MORE

  7. 10. Regulation of STAT5 activity by growth hormone

    Author : Tony J Pircher; Karolinska Institutet; Karolinska Institutet; []
    Keywords : growth hormone janus kinase; STAT5; MAP kinase; phosphatase;

    Abstract : The growth hormone (GH) receptor is a member of the cytokine receptor superfamily. This receptor family has certain common characteristics, among them the absence of a canonical tyrosine kinase consensus sequence and the association with the Janus family of cytosolic tyrosine kinases (JAK). The predominant JAK utilized by the GH receptor is JAK2. READ MORE