Search for dissertations about: "Stat3"

Showing result 11 - 15 of 80 swedish dissertations containing the word Stat3.

  2. 11. Shedding light on the STAT3 small molecule inhibitor field

    Author : Sander Busker; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. READ MORE

  4. 12. GALIELLALACTONE ANALOGUES – SYNTHESIS AND PROPERTIES

    Author : Ritha Gidlöf; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galiellalactone; one-pot peptide coupling and intramolecular Michael addition; tandem palladium-catalyzed carbonylation intramolecular Diels-Alder; STAT3 inhibition;

    Abstract : Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. READ MORE

  5. 13. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Author : Martin H Johansson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Abstract : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. READ MORE

  6. 14. Studies on the role of SOCS3 and STAT3 in development and function of the immune system

    Author : Yu Gao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the innate host defenses and establish the infection in the host. READ MORE

  7. 15. Molecular mechanisms of antidiabetic effects of estrogen

    Author : Galyna Bryzgalova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Estrogen; glucose tolerance; insulin sensitivity; lipogenic genes; Lepr; Stat3; G6pc; Srebp1c;

    Abstract : The role of estrogen in the development and regulation of female reproduction is well established. However, recent studies demonstrate that estrogen has a multiple effects on body functions. At present, it is becoming well recognized that one of the important roles of estrogen is the maintenance of glucose homeostasis. READ MORE