Search for dissertations about: "Stat3"

Showing result 16 - 20 of 80 swedish dissertations containing the word Stat3.

  2. 16. Brain control of energy balance : localization and regulation of proteins involved in the central control of food intake and body weight

    Author : Maria Collin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AGRP; arcuate nucleus; brainstem; CART; GABA; Glutamate; GPCR; habenular complex; immunohistochemistry; in situ hybridization; hypothalamus; leptin; leptin receptor; LHA; MCH; NPY; Ob-Rb; POMC; serotonin; STAT3; transporter; ventromedial hypothalamic nucleus; VGLUT1-3.;

    Abstract : Obesity has become a worldwide threat to human well-being and is now so common that it is beginning to replace undernutrition and infectious disease as the most significant contributor to ill health. Obesity increases the risk for aquiring serious diseases such as diabetes type 2, hypertension, coronary heart disease and certain forms of cancer. READ MORE

  4. 17. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

    Author : Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

    Abstract : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. READ MORE

  5. 18. Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer

    Author : Elin Edsbäcker; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, these features are unique to each individual tumor and therefore a personalized treatment regimen needs to be composed for each patient. READ MORE

  6. 19. Therapeutic response in human cancers : the dual role of STAT signalling

    Author : Iryna Kolosenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : STAT proteins were discovered as the mediators of interferon (IFN) signalling in response to viral infections. Later, it has become evident that STATs are activated by many stimuli and that they exert multifaceted effects by regulating gene transcription. READ MORE

  7. 20. Oncogenic ALK signaling in neuroblastoma

    Author : Ganesh Umapathy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; neuroblastoma; ERK5; Akt; MYCN; mTOR;

    Abstract : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. READ MORE