Search for dissertations about: "Stat3"

Showing result 21 - 25 of 80 swedish dissertations containing the word Stat3.

  2. 21. Regulation of molecular processes in diffuse large B-cell lymphoma

    Author : Therese Högfeldt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The molecular understanding of diseases has advanced rapidly due to the use of gene expression profiling. However, these methods have been hampered by the limitation to use frozen tissue specimens. Formalin fixation and paraffin embedding (FFPE) is a standard procedure for long time storage of tissues. READ MORE

  4. 22. Mechanisms of modulation of PDGFRβ signaling

    Author : Niki Sarri; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signalling; phosphatase; MKP2; DUSP4; deubiquitinase; USP4; USP17; E3 ligase; Cbl; TRIM21; endoribonuclease; G3BP1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Platelet-derived growth factors (PDGF) constitute a family of five functional dimers that bind to two structurally related tyrosine kinase receptors i.e. PDGF receptor α and β (PDGFRα and PDGFRβ, respectively), controlling cell growth, proliferation, and migration in cells of mesenchymal origin. READ MORE

  5. 23. Studies on the effect of ErbB tyrosine kinase inhibitors on malignant melanoma growth and survival in vitro

    Author : Emelie Djerf; Thomas Walz; Anna-Lotta Hallbeck; Olle Stål; Curt Peterson; Johan Hansson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Malignant melanoma has one of the fastest increasing incidences among the different types of cancerin the Western world. This raise can partly be ascribed to the change in sun habits that has takenplace during the last decades, since the major external risk factor for melanoma is exposure toultraviolet radiation. READ MORE

  6. 24. Identification of novel inducers for LL-37 expression : assay development and mechanistic studies

    Author : Frank Nylén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The remaining reservoir of effective antibiotics is running out and more and more pathogens are gaining resistance, even to the last line of antibiotics. Therefore, novel treatment regimens against bacterial infections are urgently needed. READ MORE

  7. 25. Regulators of glucose and lipid metabolism in skeletal muscle and serum : implications for obesity and type 2 diabetes

    Author : Fredirick Mashili; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 2 diabetes mellitus (T2DM) has become a growing worldwide problem of public health importance. Insulin resistance is commonly associated with obesity and a key factor mediating the progression to T2DM. READ MORE