Search for dissertations about: "Stem Cells metabolism"
Showing result 1 - 5 of 54 swedish dissertations containing the words Stem Cells metabolism.
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1. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors
Abstract : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. READ MORE
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2. Stem cells for cardiac regeneration
Abstract : Recent studies have demonstrated a turnover of cardiomyocytes throughout the adult life. Whether this regenerative potential is due to proliferation and differentiation of resident stem cells or to the dedifferentiation of adult cardiomyocytes remains unclear. READ MORE
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3. RNA modifications and post-transcriptional control in cancer and stem cells
Abstract : Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. READ MORE
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4. Neural stam cells, TLX, and Neuroblastoma
Abstract : Neuroblastoma (NB) is one of the most commonly diagnosed extracranial tumors in children below five years of age. Moreover, NB accounts for almost 12-15% of all childhood cancer related fatalities. To date, the origin of NB has been linked to the neural crest derived sympathoadrenal progenitor cells. READ MORE
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5. Stem cell-based models to study cellular alterations in Parkinson’s Disease
Abstract : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. READ MORE