Search for dissertations about: "Stereoselectivity"

Showing result 1 - 5 of 54 swedish dissertations containing the word Stereoselectivity.

  1. 1. 1. Asymmetric aldol and alkylation reactions using pyrrolidine-based chiral auxiliaries 2. Syntheses of pine sawfly pheromone precursors and structurally related compounds

    University dissertation from Stockholm : Kemi

    Author : Fredrik Andersson; KTH.; Mittuniversitetet.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chiral auxiliary; Stereoselectivity; Lewis acid; Aldol; Alkylation; Sex pheromone; Pine sawfly; Lipase; Synthesis; Diprion nipponica; Macrodiprion memoralis; Microdiprion pallipes; ; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi;

    Abstract : This thesis describes the syntheses of the 1-propionylatedauxiliaries (S)-(− )-2-(pyrrolidin-2-yl)propan-2-ol and (S)-(− )-2-(1-methoxy-1-methylethyl)pyrrolidine andtheir use in asymmetric aldol and alkylation reactions. Thesynthesis of 1-propionylated (2S,4R) 2-{4-[(tert-butyldimethylsilyl)oxy]pyrrolidin-2-yl}propan-2-olis also described. READ MORE

  2. 2. Engineered Alcohol Dehydrogenases for Stereoselective Chemical Transformations

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Thilak Reddy Enugala; Uppsala universitet.; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; alcohol dehydrogenase-A; biocatalysts; protein engineering; enzyme kinetics; sec-alcohols; ketones; stereoselectivity; regioselectivity; substrate selectivity and promiscuity.; Biokemi; Biochemistry;

    Abstract : Enzymes are biomolecules built from amino acids and catalyze the chemical transformations in a cell. Enzymes are by nature stereoselective, biodegradable, environmentally friendly, and can perform catalysis in aqueous solutions and at ambient temperatures. READ MORE

  3. 3. Heck Reactions with Aryl Chlorides Studies of Regio- and Stereoselectivity

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Gopal K. Datta; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heck reaction; aryl chloride; vinyl ether; regioselective; stereoselective; palladium; chelation control; microwave; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi;

    Abstract : Homogeneous palladium-catalyzed Heck vinylation of aryl chlorides was investigated under air using Herrmann’s palladacycle and the P(t-Bu)3-liberating salt [(t-Bu)3PH]BF4. Based on the results, controlled microwave heating was utilized to accelerate model Heck reactions with aryl chlorides down to 30 min employing an electron-poor olefin and a mixture of an ionic liquid and 1,4-dioxane as solvent. READ MORE

  4. 4. Evolutionary Analysis and Posttranslational Chemical Modifications in Protein Redesign A Study on Mu Class Glutathione Transferases

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ylva Ivarsson; Uppsala universitet.; [2006]
    Keywords : Biochemistry; glutathione transferase; evolutionary analysis; positive selection; epoxide; stereoselectivity; protein modification; Biokemi;

    Abstract : Glutathione transferases (GSTs) constitute a family of multifarious enzymes that conjugate glutathione (GSH) with a wide range of electrophiles. GSTs are grouped into different classes based on protein sequence similarities. Despite high sequence identities between GSTs of the same class they often display different substrate specificites. READ MORE

  5. 5. On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Rasmus Jansson Löfmark; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human African trypanosomiasis; HAT; Pharmacokinetics; NONMEM; Stereoselectivity; Eflornithine; Tissue distribution;

    Abstract : Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is efficacious but the cumbersome intravenous administration leaves numerous patients untreated. READ MORE