Search for dissertations about: "Stereoselectivity"

Showing result 6 - 10 of 61 swedish dissertations containing the word Stereoselectivity.

  2. 6. On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios

    Author : Rasmus Jansson Löfmark; Göteborgs universitet; []
    Keywords : Human African trypanosomiasis; HAT; Pharmacokinetics; NONMEM; Stereoselectivity; Eflornithine; Tissue distribution;

    Abstract : Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is efficacious but the cumbersome intravenous administration leaves numerous patients untreated. READ MORE

  4. 7. On the Ring-Opening Reaction of Thiophene-1,1-dioxides and the Intramolecular Diels-Alder Reaction of Azanona- and AzadecatrienesI

    Author : Anders Sebastian Tsirk; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transition states; 3-21G * ; intramolecular Diels-Alder reactions; asymmetric induction; multivariate optimization; kinetic isotope effects; rearrangements; secondary amines; 1-dioxides; Ring-opening reaction; thiophene-1; stereoselectivity.; Organic chemistry; Organisk kemi;

    Abstract : Substituted thiophene-1,1-dioxides were synthesized and their ring-opening reactions with omega-unsaturated secondary amines were investigated; this led to a synthetic route to azatrienes and to the preparation of some polyhydroisoindoles and polyhydroisoquinolines via an intramolecular Diels-Alder reaction. By using 2-substituted pyrrolidines and piperidines various tetrahydrobenzo[f]indolizidines, benzo[b]quinolizidines, tetrahydrobenzo[a]indolizidines and tetrahydro[a]pyrrolizidines could be synthesized via the ring-opening of 3-bromo-2,5-dimmethylthiophene-1,1-dioxide and a subsequent intramolecular Diels-Alder reaction. READ MORE

  5. 8. Carboligation using the aldol reaction : A comparison of stereoselectivity and methods

    Author : Derar Al-Smadi; Mikael Widersten; Ulf Nilsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aldol reaction; cinchonine; FSA enzyme; homologation reactions; phenylacetaldehyde derivatives; samarium diiodide.;

    Abstract : The research summarized in this thesis focuses on synthesizing aldehyde and aldol compounds as substrates and products for the enzyme D-fructose-6-aldolase (FSA). Aldolases are important enzymes for the formation of carbon-carbon bonds in nature. READ MORE

  6. 9. Prototropy in the indene system : studies in synthesis, stereoselectivity and ratestructure correlations

    Author : Lennart Meurling; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  7. 10. Centrally acting dopamine receptor stimulants with special reference to dopamine autoreceptors and stereoselectivity

    Author : Håkan Wikström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE