Search for dissertations about: "Steven Dowdy"

Found 3 swedish dissertations containing the words Steven Dowdy.

  2. 1. Cell-penetrating peptides; chemical modification, mechanism of uptake and formulation development

    Author : Kariem Ezzat; Ülo Langel; Steven Dowdy; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell penetrating peptides; gene therapy; scavenger receptors; pharmaceutical formulation; solid dispersion; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Gene therapy holds the promise of revolutionizing the way we treat diseases. By using recombinant DNA and oligonucleotides (ONs), gene functions can be restored, altered or silenced according to the therapeutic need. READ MORE

  4. 2. Biophysical studies of peptides with functions in biotechnology and biology

    Author : Fatemeh Madani; Astrid Gräslund; Steven F. Dowdy; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetic fluorescence label; Biarsenical tetracysteine motif; Cell-penetrating peptides; Large unilamellar vesicles; Pyrenebutyrate; Endosomal escape; Membrane perturbation; Bacteriorhodopsin; Dynorphin; Biophysics; biofysik;

    Abstract : My thesis concerns spectroscopic studies (NMR, CD and fluorescence) of peptides with functions in biotechnology and biology, and their interactions with a model membrane (large unilamellar phospholipid vesicles).The resorufin-based arsenical hairpin binder (ReAsH) bound to a short peptide is a useful fluorescent tag for genetic labeling of proteins in living cells. READ MORE

  5. 3. Cell-penetrating peptides in model membrane systems : Interaction, structure induction and membrane effects

    Author : Mazin Magzoub; Astrid Gräslund; Steven Dowdy; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik;

    Abstract : Despite continuing advances in the development of macromolecules, including peptides, proteins, and oligonucleotides, for therapeutic purposes, the successful application of these hydrophilic molecules has so far been hampered by their inability to efficiently traverse the plasma membrane. The discovery of a class of peptides (cell-penetrating peptides, CPPs) with the ability to mediate the non-invasive and efficient import of a whole host of cargoes, both in vitro and in vivo, has provided a new means by which the problem associated with cellular delivery can be circumvented. READ MORE