Search for dissertations about: "Striatal synaptic plasticity"

Showing result 1 - 5 of 12 swedish dissertations containing the words Striatal synaptic plasticity.

  2. 1. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity

    Author : Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez-Arenas; Upinder S. Bhalla; Pierre Vincent; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatal synaptic plasticity; LTP; Dopamine; Acetylcholine; Synergy; Medium spiny neurons; MSNs;

    Abstract : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. READ MORE

  4. 2. Synaptic transmission and synaptic plasticity in the mouse striatum

    Author : Sietske Schotanus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. READ MORE

  5. 3. Striatal glutamatergic neurotransmission and plasticity in Parkinson’s disease and aging

    Author : Mona Nouhi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson's disease (PD) is a devastating neurodegenerative disorder with aging as the main risk factor. PD is characterized by severe movement disturbances but is also associated with non-motor symptoms. READ MORE

  6. 4. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia

    Author : Tim Fieblinger; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Parkinson’s disease; L-DOPA-induced dyskinesia; ERK1 2; mGluR5; homeostatic plasticity; SPN; 2‑Photon microscopy;

    Abstract : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. READ MORE

  7. 5. Non-linear synaptic integration on dendrites of striatal medium-spiny neuron : a computational study

    Author : Kai Du; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Striatum is the main input nucleus of basal ganglia. Medium-spiny neurons (MSNs), the principal neurons of the striatum, receive convergent excitatory inputs from cortex and thalamus, thus “gate” the information flow to the basal ganglia. READ MORE