Search for dissertations about: "Stringent response"

Showing result 11 - 15 of 48 swedish dissertations containing the words Stringent response.

  2. 11. Dynamics in Protein Synthesis, Structural Studies of Translation Factors

    Author : Martin Laurberg; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Flexibility; Fusidic Acid; tRNA; Translation Factors; Ribosome; Molekylär biofysik;

    Abstract : Protein biosynthesis is performed on ribosomes. The ribosome is a complex of ribosomal RNA and proteins forming two subunits. A messenger RNA strand is decoded on the small subunit by charged aminoacyl transfer RNA (aa-tRNA) molecules and each tRNA molecule delivers its amino acid to the growing polypeptide chain on the large subunit. READ MORE

  4. 12. Systems-level investigation of the interaction between glucose metabolism and the Snf1/Mig1 signalling pathway

    Author : Niek Welkenhuysen; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glucose signalling; microfluidics; Saccharomyces cerevisiae;

    Abstract : Saccharomyces cerevisiae Snf1 and its mammalian homolog, AMPK, are members of a protein kinase family present throughout the Eukaryotic kingdom. AMPK plays an essential role in different cellular processes and is involved in diseases such as diabetes, obesity and cancer. READ MORE

  5. 13. Intracellular Flows and Fluctuations

    Author : Johan Elf; Måns Ehrenberg; Peter Wolynes; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; mesoscopic; reaction-diffusion; protein synthesis; amino acid; flow; fluctuations; Molekylärbiologi; Molecular biology; Molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Mathematical models are now gaining in importance for descriptions of biological processes. In this thesis, such models have been used to identify and analyze principles that govern bacterial protein synthesis under amino acid limitation. READ MORE

  6. 14. Studies on Redox-proteins and Cytokines in inflammation and Cancer

    Author : Akter Hossain; Anders Rosén; Christer Lindqvist; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thioredoxin Trx ; Selenium; Tumor necrosis factor TNF ; Cancer; nflammation; oxidative stress; Protein-disulfide isomerase PDI ; Tumor necrosis factor receptor TNFR ; Medical cell biology; Medicinsk cellbiologi;

    Abstract : The redox state in the cell plays a major role in determining vital functions and its major imbalance can lead to severe cell injury or death. Redox active proteins and cytokines involved in this process includes thioredoxin (Trx), protein disulfide isomerase (PDI), and tumor necrosis factor (TNF) superfamilies. READ MORE

  7. 15. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

    Author : Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

    Abstract : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. READ MORE