Search for dissertations about: "Structural changes"
Showing result 1 - 5 of 1194 swedish dissertations containing the words Structural changes.
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1. Visualizing structural dynamics: from small molecules to membrane proteins
Abstract : To fully understand the mechanism of a chemical reaction, it is important to characterize the rapid structural dynamics of transient chemical species as the reaction propagates. Since chemical processes are heavily influenced by the solvent in which they occur, the interaction with the surrounding solution also needs to be elucidated. READ MORE
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2. Transthyretin and the transthyretin-related protein: A structural study
Abstract : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. READ MORE
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3. Structural basis for metalloprotein catalysis : Characterization of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase PgsA1 and Bacillus anthracis ribonucleotide reductase R2
Abstract : About a third of all proteins need to associate with a particular metal ion or metallo-inorganic cofactor to function. This interplay expands the catalytic repertoire of enzymes and reflects the adaption of these catalytic macromolecules to the environments they have evolved in. READ MORE
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4. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents
Abstract : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. READ MORE
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5. Structural transitions of proton-gated ion channels : Involving pH sensing, heterogeneity and lipid interactions
Abstract : Studying protein structure and function involves analyzing the relationship between a protein's three-dimensional assembly and its dynamic biochemical activity. The superfamily of pentameric ligand-gated ion channels (pLGICs) constitutes a classic yet illuminating experimental system for structure-function studies. READ MORE