Search for dissertations about: "Structural changes"

Showing result 1 - 5 of 1124 swedish dissertations containing the words Structural changes.

  2. 1. Transthyretin and the transthyretin-related protein: A structural study

    Author : Erik Lundberg; A. Elisabeth Sauer-Eriksson; Lennart Sjölin; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Transthyretin-related protein; X-ray crystallography; Protein structure; Amyloidosis; Structural biology; Strukturbiologi;

    Abstract : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. READ MORE

  4. 2. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents

    Author : Wojciech W. Krajewski; Sherry L. Mowbray; Torsten Unge; Thomas C. Terwilliger; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Structural biology; Strukturbiologi;

    Abstract : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. READ MORE

  5. 3. The aged brain : structural changes and cognitive function

    Author : Hedvig Söderlund; Lena Lyons; Stockholms universitet; []
    Keywords : SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; Brain; Cognitive processes; Aging; Åldrandets psykologi; Kognitiva processer; Hjärna;

    Abstract : .... READ MORE

  6. 4. Transition Metal Hydride Complexes and Hydrogenated Gallium Clusters : Synthesis and Structural Properties

    Author : Henrik Fahlquist; Dag Noréus; Maximilian Fichtner; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Metal hydrides; Solid state Synthesis; X-ray diffraction; Neutron Scattering; strukturkemi; Structural Chemistry;

    Abstract : Synthesis and structural characterisation of metal hydrides in two important systems are presented. The first system presented is low valent cobalt and nickel complex hydrides with the compositions BaMg5Co2H10, RbMg5CoNiH10, SrMg2CoH7and Sr4Mg4Co3H19 featuring nickel with oxidation state of 0 and cobalt with oxidation state +I and -I. READ MORE

  7. 5. Structural studies of small viruses using an X-ray Free Electron Laser

    Author : Anna Munke; Marvin Seibert; Dirk Hasse; Inger Andersson; Carl Caleman; Maria Selmer; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : X-ray crystallography has since its introduction been the most successful technique for solving protein structures. Viruses however, often possess structural components such as fibrils, tails and envelopes that make them difficult or impossible to crystallize. READ MORE