Search for dissertations about: "Structural variants"
Showing result 1 - 5 of 172 swedish dissertations containing the words Structural variants.
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1. Structural studies of proteins in apoptosis and lipid signaling
Abstract : Signaling pathways control the fate of the cell. For example, they promote cell survival or commit the cell to death (apoptosis) in response to cell injury or developmental stimuli, decisions, which are vital for the proper development and functioning of metazoan. READ MORE
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2. Structural assessment procedures for existing concrete bridges : Experiences from failure tests of the Kiruna Bridge
Abstract : Assessing existing bridges is an important task in the sustainable management ofinfrastructure. In practice, structural bridge assessments are usually conducted usingtraditional and standardised methods, despite knowledge that these methods oftenprovide conservative estimates. READ MORE
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3. Thiopurine S-methyltransferase - characterization of variants and ligand binding
Abstract : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. READ MORE
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4. Sequence- and structure guided engineering of proteins and enzymes for biotechnology and health applications
Abstract : Proteins are highly diverse and sophisticated biomolecules that represent a cornerstone of biological structure and function and have been exploited in man-made applications for thousands of years. Those proteins that facilitate chemical reactions at physiologically relevant time-scales are referred to as enzymes. READ MORE
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5. The hematopoietic transcription factor RUNX1 : a structural view
Abstract : The malfunction of the transcriptional regulator RUNX1 is the major cause of several variants of acute human leukemias and its normal function is to regulate the development of the blood system in concert with other transcriptional co-regulators. RUNX1 belongs to a conserved family of heterodimeric transcription factors that share a conserved DNA binding domain, the Runt domain (RD), named after the first member of this group – Runt - found in Drosophila melanogaster. READ MORE